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http://dx.doi.org/10.25673/110444
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DC Field | Value | Language |
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dc.contributor.author | Rachidi, Fanny | - |
dc.contributor.author | Wagner, Romy | - |
dc.contributor.author | Fieseler, Helena | - |
dc.contributor.author | Kaiser, Matthias | - |
dc.contributor.author | Müller, Hendrik | - |
dc.contributor.author | Podpecan, Ozbalt | - |
dc.contributor.author | Mielenz, Norbert | - |
dc.contributor.author | Gottschalk, Jutta | - |
dc.contributor.author | Einspanier, Almuth | - |
dc.contributor.author | Möbius, Gerd | - |
dc.contributor.author | Baumgartner, Walter | - |
dc.contributor.author | Starke, Alexander | - |
dc.date.accessioned | 2023-09-14T07:09:53Z | - |
dc.date.available | 2023-09-14T07:09:53Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/112399 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/110444 | - |
dc.description.abstract | Introduction: The effect of a targeted pain management protocol consisting of sedation and local anesthesia on the stress response to treatment of dermatitis interdigitalis contagiosa (DINCO) was assessed in sheep placed in dorsal recumbency. Methods: Blood cortisol concentrations were measured once a day (Day -3 to 2) and additionally on day 0, six times during the claw treatment (stress model). Twelve healthy sheep (control group; HEALTHY) and 36 sheep with DINCO, randomly allocated to one of three treatment groups, underwent the stress model with or without pain control: the XYLA-IVRA sheep were sedated with 2% xylazine hydrochloride (XYLA) and received retrograde intravenous regional anesthesia (IVRA); the IVRA sheep underwent IVRA and received a placebo instead of sedation; the PLACEBO sheep received placebos for sedation and IVRA. The HEALTHY sheep underwent sham claw treatment and received placebos. Results and discussion: The cortisol concentrations were higher in sheep restrained in dorsal recumbency compared with the cortisol concentrations measured four hours later in standing sheep (HEALTHY 37.2 ± 3.3 ng/ml vs. 18.5 ± 3.3 ng/ml; DISEASED 34.0 ± 1.9 ng/ml vs. 17.6 ± 1.9 ng/ml; p < 0.001). The stress response of XYLA-IVRA (area under the curve; AUC = 34.9 ± 2.6 ng/ml) was reduced compared with the stress response of PLACEBO (AUC = 48.0 ± 2.6 ng/ml, p < 0.01) and HEALTHY sheep (AUC = 46.6 ± 2.5 ng/ml; p = 0.01). While cortisol concentration of XYLA-IVRA and HEALTHY sheep did not increase one day after the stress model (Day 1) compared with the day of the stress model (Day 0), both PLACEBO (47.4 ± 3.3 vs. 35.6 ± 3.1 ng/ml, p = 0.02) and IVRA sheep (39.1 ± 2.8 vs. 28.6 ± 3.1 ng/ml, p = 0.01) had higher cortisol concentrations. The results confirm that fixation in dorsal recumbency in a tilt squeeze chute was a major stressor in sheep. The differences in the cortisol concentration of the PLACEBO sheep versus the XYLA-IVRA sheep during and after the stress model illustrate the effect and necessity of pain management protocols in practice. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 599 | - |
dc.title | Effect of a targeted pain management protocol for the treatment of dermatitis interdigitalis contagiosa in Merino meat sheep in a tilt squeeze chute | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Frontiers in animal science | - |
local.bibliographicCitation.volume | 3 | - |
local.bibliographicCitation.pagestart | 1 | - |
local.bibliographicCitation.pageend | 16 | - |
local.bibliographicCitation.publishername | Frontiers Media | - |
local.bibliographicCitation.publisherplace | Lausanne | - |
local.bibliographicCitation.doi | 10.3389/fanim.2022.1021039 | - |
local.subject.keywords | cortisol, stress, dorsal recumbency, tilt squeeze chute, claw treatment, regional anesthesia, sedation, pain mitigation | - |
local.openaccess | true | - |
dc.identifier.ppn | 1859501885 | - |
cbs.publication.displayform | 2022 | - |
local.bibliographicCitation.year | 2022 | - |
cbs.sru.importDate | 2023-09-14T07:09:14Z | - |
local.bibliographicCitation | Enthalten in Frontiers in animal science - Lausanne : Frontiers Media, 2020 | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
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fanim-03-1021039.pdf | 880.04 kB | Adobe PDF | ![]() View/Open |