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Title: Imaging of peripheral vascular malformations : current concepts and future perspectives
Author(s): Schmidt, Vanessa F.
Masthoff, Max
Czihal, Michael
Cucuruz, Beatrix
Häberle, BeateLook up in the Integrated Authority File of the German National Library
Brill, RichardLook up in the Integrated Authority File of the German National Library
Wohlgemuth, Walter A.Look up in the Integrated Authority File of the German National Library
Wildgruber, MoritzLook up in the Integrated Authority File of the German National Library
Issue Date: 2021
Type: Article
Language: English
Abstract: Vascular Malformations belong to the spectrum of orphan diseases and can involve all segments of the vascular tree: arteries, capillaries, and veins, and similarly the lymphatic vasculature. The classification according to the International Society for the Study of Vascular Anomalies (ISSVA) is of major importance to guide proper treatment. Imaging plays a crucial role to classify vascular malformations according to their dominant vessel type, anatomical extension, and flow pattern. Several imaging concepts including color-coded Duplex ultrasound/contrast-enhanced ultrasound (CDUS/CEUS), 4D computed tomography angiography (CTA), magnetic resonance imaging (MRI) including dynamic contrast-enhanced MR-angiography (DCE-MRA), and conventional arterial and venous angiography are established in the current clinical routine. Besides the very heterogenous phenotypes of vascular malformations, molecular and genetic profiling has recently offered an advanced understanding of the pathogenesis and progression of these lesions. As distinct molecular subtypes may be suitable for targeted therapies, capturing certain patterns by means of molecular imaging could enhance non-invasive diagnostics of vascular malformations. This review provides an overview of subtype-specific imaging and established imaging modalities, as well as future perspectives of novel functional and molecular imaging approaches. We highlight recent pioneering imaging studies including thermography, positron emission tomography (PET), and multispectral optoacoustic tomography (MSOT), which have successfully targeted specific biomarkers of vascular malformations.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Molecular and Cellular Pediatrics
Publisher: SpringerOpen
Publisher Place: Berlin
Volume: 8
Issue: 1
Original Publication: 10.1186/s40348-021-00132-w
Page Start: 1
Page End: 18
Appears in Collections:Open Access Publikationen der MLU

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