Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/111386
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DC Field | Value | Language |
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dc.contributor.author | Szardenings, Michael | - |
dc.contributor.author | Delaroque, Nicolas | - |
dc.contributor.author | Kern, Karolin | - |
dc.contributor.author | Ramirez-Caballero, Lisbeth | - |
dc.contributor.author | Puder, Marcus | - |
dc.contributor.author | Ehrentreich-Förster, Eva | - |
dc.contributor.author | Beige, Joachim | - |
dc.contributor.author | Zürner, Sebastian | - |
dc.contributor.author | Popp, Georg | - |
dc.contributor.author | Wolf, Johannes | - |
dc.contributor.author | Borte, Stephan M. | - |
dc.date.accessioned | 2023-10-26T06:40:03Z | - |
dc.date.available | 2023-10-26T06:40:03Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/113340 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/111386 | - |
dc.description.abstract | (1) Background: Coronavirus proteins are quite conserved amongst endemic strains (eCoV) and SARS-CoV-2. We aimed to evaluate whether peptide epitopes might serve as useful diagnostic biomarkers to stratify previous infections and COVID-19. (2) Methods: Peptide epitopes were identified at an amino acid resolution that applied a novel statistical approach to generate data sets of potential antibody binding peptides. (3) Results: Data sets from more than 120 COVID-19 or eCoV-infected patients, as well as vaccinated persons, have been used to generate data sets that have been used to search in silico for potential epitopes in proteins of SARS-CoV-2 and eCoV. Peptide epitopes were validated with >300 serum samples in synthetic peptide micro arrays and epitopes specific for different viruses, in addition to the identified cross reactive epitopes. (4) Conclusions: Most patients develop antibodies against non-structural proteins, which are useful general markers for recent infections. However, there are differences in the epitope patterns of COVID-19, and eCoV, and the S-protein vaccine, which can only be explained by a high degree of cross-reactivity between the viruses, a pre-existing immune response against some epitopes, and even an alternate processing of the vaccine proteins. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | Detection of antibodies against endemic and SARS-CoV-2 coronaviruses with short peptide epitopes | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Vaccines | - |
local.bibliographicCitation.volume | 11 | - |
local.bibliographicCitation.issue | 9 | - |
local.bibliographicCitation.pagestart | 1 | - |
local.bibliographicCitation.pageend | 18 | - |
local.bibliographicCitation.publishername | MDPI | - |
local.bibliographicCitation.publisherplace | Basel | - |
local.bibliographicCitation.doi | 10.3390/vaccines11091403 | - |
local.subject.keywords | coronavirus; COVID-19; epitopes; cross-reactivity; serology; peptide array; array image processing; biomarkers | - |
local.openaccess | true | - |
dc.identifier.ppn | 1868086763 | - |
cbs.publication.displayform | 2023 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2023-10-26T06:39:42Z | - |
local.bibliographicCitation | Enthalten in Vaccines - Basel : MDPI, 2013 | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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vaccines-11-01403.pdf | 5.89 MB | Adobe PDF | View/Open |