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http://dx.doi.org/10.25673/115078
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DC Field | Value | Language |
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dc.contributor.author | Oeckl, Patrick | - |
dc.contributor.author | Bluma, Marina | - |
dc.contributor.author | Bucci, Marco | - |
dc.contributor.author | Halbgebauer, Steffen | - |
dc.contributor.author | Chiotis, Konstantinos | - |
dc.contributor.author | Sandebring-Matton, Anna | - |
dc.contributor.author | Ashton, Nicholas J. | - |
dc.contributor.author | Molfetta, Guglielmo | - |
dc.contributor.author | Grötschel, Lana | - |
dc.contributor.author | Kivipelto, Miia | - |
dc.contributor.author | Blennow, Kaj | - |
dc.contributor.author | Zetterberg, Henrik | - |
dc.contributor.author | Savitcheva, Irina | - |
dc.contributor.author | Nordberg, Agneta | - |
dc.contributor.author | Otto, Markus | - |
dc.date.accessioned | 2024-03-04T07:19:16Z | - |
dc.date.available | 2024-03-04T07:19:16Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/117034 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/115078 | - |
dc.description.abstract | Introduction: β-synuclein is an emerging blood biomarker to study synaptic degeneration in Alzheimer´s disease (AD), but its relation to amyloid-β (Αβ) pathology is unclear. Methods: We investigated the association of plasma β-synuclein levels with [18F]flutemetamol positron emission tomography (PET) in patients with AD dementia (n = 51), mild cognitive impairment (MCI–Aβ+ n = 18, MCI– Aβ– n = 30), non-AD dementias (n = 22), and non-demented controls (n = 5). Results: Plasma β-synuclein levels were higher in Aβ+ (AD dementia, MCI–Aβ+) than in Aβ– subjects (non-AD dementias, MCI–Aβ−) with good discrimination of Aβ+ from Aβ– subjects and prediction of Aβ status in MCI individuals. A positive correlation between plasma β-synuclein and Aβ PET was observed in multiple cortical regions across all lobes. Discussion: Plasma β-synuclein demonstrated discriminative properties for Aβ PET positive and negative subjects. Our data underline that β-synuclein is not a direct marker of Aβ pathology and suggest different longitudinal dynamics of synaptic degeneration versus amyloid deposition across the AD continuum. Highlights: Blood and CSF β-synuclein levels are higher in Aβ+ than in Aβ− subjects. Blood β-synuclein level correlates with amyloid PET positivity in multiple regions. Blood β-synuclein predicts Aβ status in MCI individuals. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | Blood β-synuclein is related to amyloid PET positivity in memory clinic patients | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Alzheimer's and dementia | - |
local.bibliographicCitation.volume | 19 | - |
local.bibliographicCitation.issue | 11 | - |
local.bibliographicCitation.pagestart | 4896 | - |
local.bibliographicCitation.pageend | 4907 | - |
local.bibliographicCitation.publishername | Wiley | - |
local.bibliographicCitation.publisherplace | Hoboken, NJ | - |
local.bibliographicCitation.doi | 10.1002/alz.13046 | - |
local.subject.keywords | Alzheimert’s disease, amyloid beta PET, blood biomarker, synaptic degeneration, β-synuclein | - |
local.openaccess | true | - |
dc.identifier.ppn | 1848147570 | - |
cbs.publication.displayform | 2023 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2024-03-04T07:18:27Z | - |
local.bibliographicCitation | Enthalten in Alzheimer's and dementia - Hoboken, NJ : Wiley, 2005 | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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Alzheimer s Dementia - 2023 - Oeckl - Blood ‐synuclein is related to amyloid PET positivity in memory clinic patients.pdf | 1.57 MB | Adobe PDF | View/Open |