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http://dx.doi.org/10.25673/115089
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DC Element | Wert | Sprache |
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dc.contributor.author | Schultheiß, Michael | - |
dc.contributor.author | Staubach-Renz, Petra | - |
dc.contributor.author | Nikolakis, Georgios | - |
dc.contributor.author | Schollenberger, Lukas | - |
dc.contributor.author | Mauch, Melanie | - |
dc.contributor.author | Burckhardt, Marion | - |
dc.contributor.author | Heise, Marcus | - |
dc.contributor.author | Zamsheva, Marina | - |
dc.contributor.author | Strobel, Alexandra | - |
dc.contributor.author | Langer, Gero | - |
dc.contributor.author | Bechara, Falk Georges | - |
dc.contributor.author | Kirschner, Uwe Manfred | - |
dc.contributor.author | Hennig, Katharina | - |
dc.contributor.author | Kunte, Christian | - |
dc.contributor.author | Goebeler, Matthias | - |
dc.contributor.author | Grabbe, Stephan | - |
dc.date.accessioned | 2024-03-04T07:38:24Z | - |
dc.date.available | 2024-03-04T07:38:24Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/117045 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/115089 | - |
dc.description.abstract | Background: Hidradenitis suppurativa (HS) is an inflammatory disease of the inverse skin regions that occurs in young women, in particular, and affects approximately 1% of the population. Outpatient care is often inadequate and usually cannot prevent progression. Objectives: To evaluate in the EsmAiL (‘Evaluation eines strukturierten und leitlinienbasierten multmodalen Versorgungskonzepts für Menschen mit Akne inversa’) trial whether an innovative care concept can decrease disease activity and burden, and improve patient satisfaction. Methods: EsmAiL was conducted as a two-arm, multicentre, prospective, randomized controlled trial that included 553 adults with HS. Inclusion criteria were a minimum of three inflammatory lesions and at least a moderate impact of the disease on quality of life. The control group (CG) remained under standard care, while patients in the intervention group (IG) were treated according to a trial-specific, multimodal concept. The primary endpoint was the absolute change in International Hidradenitis Suppurativa Severity Score System (IHS4). Results: In total, 274 patients were randomized to the IG and 279 to the CG. Altogether, 377 attended the final assessment after 12 months of intervention. Participants in the IG (n = 203) achieved a mean improvement in IHS4 of 9.3 points, while the average decrease in IHS4 in patients in the CG (n = 174) was 5.7 points (P = 0.003). Patients treated under the new care concept also reported a statistically significantly higher decrease in pain, Dermatology Life Quality Index and Hospital Anxiety and Depression Scale scores compared with those in the CG (P < 0.001). Patient satisfaction was also statistically significantly higher in the IG compared with the CG (P < 0.001). Conclusions: The establishment of standardized treatment algorithms in so-called ‘acne inversa centres’ in the ambulatory setting has a substantial, positive impact on the course of HS and significantly improves patient satisfaction. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | A centre-based, ambulatory care concept for Hidradenitis suppurativa improves disease activity, burden, and patient satisfaction : results from the randomised controlled trial EsmAiL | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | British journal of dermatology | - |
local.bibliographicCitation.volume | 189 | - |
local.bibliographicCitation.issue | 2 | - |
local.bibliographicCitation.pagestart | 170 | - |
local.bibliographicCitation.pageend | 179 | - |
local.bibliographicCitation.publishername | Oxford University Press | - |
local.bibliographicCitation.publisherplace | Oxford | - |
local.bibliographicCitation.doi | 10.1093/bjd/ljad135 | - |
local.openaccess | true | - |
dc.identifier.ppn | 1852367261 | - |
cbs.publication.displayform | 2023 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2024-03-04T07:37:36Z | - |
local.bibliographicCitation | Enthalten in British journal of dermatology - Oxford : Oxford University Press, 1892 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
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Datei | Beschreibung | Größe | Format | |
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ljad135.pdf | 1.15 MB | Adobe PDF | ![]() Öffnen/Anzeigen |