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http://dx.doi.org/10.25673/115101
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Lübbering, David | - |
dc.contributor.author | Preti, Max | - |
dc.contributor.author | Schlott, Lena | - |
dc.contributor.author | Schultheiß, Christoph | - |
dc.contributor.author | Weidemann, Sören | - |
dc.contributor.author | Lohse, Ansgar W. | - |
dc.contributor.author | Binder, Mascha | - |
dc.contributor.author | Carambia, Antonella | - |
dc.contributor.author | Herkel, Johannes | - |
dc.date.accessioned | 2024-03-04T08:36:12Z | - |
dc.date.available | 2024-03-04T08:36:12Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/117057 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/115101 | - |
dc.description.abstract | Autoreactive B cells are considered pathogenic drivers in many autoimmune dis-eases; however, it is not clear whether autoimmune B cells are invariably patho-genic or whether they can also arise as bystanders of T cell-driven autoimmunepathology. Here, we studied the B cell response in an autoantigen- and CD4+Tcell-driven model of autoimmune hepatitis (AIH), the Alb-iGP_Smarta mouse inwhich expression of a viral model antigen (GP) in hepatocytes and its recognitionby GP-specific CD4+T cells causes spontaneous AIH-like disease. T cell-drivenAIH in Alb-iGP_Smarta mice was marked by autoantibodies and hepatic infiltra-tion of plasma cells and B cells, particularly of isotype-switched memory B cells,indicating antigen-driven selection and activation. Immunosequencing of B cellreceptor repertoires confirmed B cell expansion selectively in the liver, which wasmost likely driven by the hepatic GP model antigen, as indicated by branched net-works of connected sequences and elevated levels of IgG antibodies toGP. However, intrahepatic B cells did not produce increased levels of cytokinesand their depletion with anti-CD20 antibody did not alter the CD4+T cellresponse in Alb-iGP_Smarta mice. Moreover, B cell depletion did not preventspontaneous liver inflammation and AIH-like disease in Alb-iGP_Smarta mice. Inconclusion, selection and isotype-switch of liver-infiltrating B cells was dependenton the presence of CD4+T cells recognizing liver antigen. However, recognitionof hepatic antigen by CD4+T cells and CD4+T cell-mediated hepatitis was notdependent on B cells. Thus, autoreactive B cells can be bystanders and need notbe drivers of liver inflammation in AIH. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | Autoantigen-selected B cells are bystanders in spontaneous T cell-driven experimental autoimmune hepatitis | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Immunology | - |
local.bibliographicCitation.volume | 170 | - |
local.bibliographicCitation.issue | 2 | - |
local.bibliographicCitation.pagestart | 214 | - |
local.bibliographicCitation.pageend | 229 | - |
local.bibliographicCitation.publishername | Wiley-Blackwell | - |
local.bibliographicCitation.publisherplace | Oxford [u.a.] | - |
local.bibliographicCitation.doi | 10.1111/imm.13665 | - |
local.subject.keywords | Autoimmunity, B cell, CD4 cell, liver | - |
local.openaccess | true | - |
dc.identifier.ppn | 1853235687 | - |
cbs.publication.displayform | 2023 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2024-03-04T08:35:42Z | - |
local.bibliographicCitation | Enthalten in Immunology - Oxford [u.a.] : Wiley-Blackwell, 1958 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
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Datei | Beschreibung | Größe | Format | |
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Immunology - 2023 - Lübbering - Autoantigen‐selected B cells are bystanders in spontaneous T cell‐driven experimental.pdf | 8.43 MB | Adobe PDF | ![]() Öffnen/Anzeigen |