Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/115105
Title: Presence of NOD2 mutations is not associated with hepatic or systemic hemodynamic abnormalities of cirrhosis
Author(s): Greinert, Robin
Zipprich, AlexanderLook up in the Integrated Authority File of the German National Library
Casper, MarkusLook up in the Integrated Authority File of the German National Library
Reichert, Matthias ChristianLook up in the Integrated Authority File of the German National Library
Lammert, FrankLook up in the Integrated Authority File of the German National Library
Ripoll, CristinaLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Background: Patients with cirrhosis who carry NOD2 mutations are susceptible to bacterial infections. The aim was to evaluate the association of NOD2 mutations with hepatic and systemic hemodynamics in cirrhosis. Patients and methods: This is a secondary analysis of a prospectively collected database in the context of the screening for the INCA trial (EudraCT 2013-001626-26). This cross-sectional study compared hemodynamic findings according to NOD2 status in 215 patients. Patients were genotyped for NOD2 variants (p.N289S, p.R702W, p.G908R, c.3020insC, rs72796367). Hepatic hemodynamic study and right heart catheterization were performed. Results: Patients had a median age of 59 (IQR 53–66) years, and 144 (67%) were men. Most patients (64%) were Child-Pugh stage B. Sixty-six patients (31%) carried a NOD2 mutation, which was slightly more common among Child-Pugh stage C (p = 0.05), without differences in MELD [wild-type: 13 (10–16); NOD2 variants 13 (10–18)]. No differences in hepatic and systemic hemodynamics were observed according to NOD2 status. If excluding patients on prophylactic or therapeutic antibiotics, again no association between hepatic or systemic hemodynamics and NOD2 status could be observed. Conclusion: NOD2 mutations are not associated with hepatic or systemic hemodynamic abnormalities in patients with decompensated cirrhosis, suggesting that other mechanisms leading to bacterial translocation predominate.
URI: https://opendata.uni-halle.de//handle/1981185920/117061
http://dx.doi.org/10.25673/115105
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Digestive and liver disease
Publisher: Saunders
Publisher Place: [S.l.]
Volume: 55
Issue: 10
Original Publication: 10.1016/j.dld.2023.05.016
Page Start: 1362
Page End: 1367
Appears in Collections:Open Access Publikationen der MLU

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