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http://dx.doi.org/10.25673/116117
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DC Element | Wert | Sprache |
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dc.contributor.author | Belachew, Esmael Besufikad | - |
dc.contributor.author | Desta, Adey Feleke | - |
dc.contributor.author | Deneke, Dinikisira Bekele | - |
dc.contributor.author | Gebremariam, Tewodros Yalew | - |
dc.contributor.author | Tefera, Dessalegn Abeje | - |
dc.contributor.author | Atire, Fikadu Alemu | - |
dc.contributor.author | Alemayehu, Dawit Hailu | - |
dc.contributor.author | Seyoum, Tamirayehu | - |
dc.contributor.author | Bauer, Marcus | - |
dc.contributor.author | Girma, Selfu | - |
dc.contributor.author | Sewasew, Dareskedar Tsehay | - |
dc.contributor.author | Kantelhardt, Eva Johanna | - |
dc.contributor.author | Tesfaye Sisay Tessema | - |
dc.contributor.author | Howe, Rawleigh | - |
dc.date.accessioned | 2024-05-21T07:35:54Z | - |
dc.date.available | 2024-05-21T07:35:54Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/118073 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/116117 | - |
dc.description.abstract | Introduction: Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. Materials and methods: A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis. Results The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively. Conclusion: The MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11. | eng |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/publicdomain/zero/1.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | BMC Research Notes | - |
local.bibliographicCitation.volume | 16 | - |
local.bibliographicCitation.publishername | [Verlag nicht ermittelbar] | - |
local.bibliographicCitation.publisherplace | London | - |
local.bibliographicCitation.doi | 10.1186/s13104-023-06518-5 | - |
local.openaccess | true | - |
dc.identifier.ppn | 1884054366 | - |
cbs.publication.displayform | 2023 | - |
local.bibliographicCitation.year | 2023 | - |
cbs.sru.importDate | 2024-05-21T07:34:27Z | - |
local.bibliographicCitation | Enthalten in BMC Research Notes - London : [Verlag nicht ermittelbar], 2008 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
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s13104-023-06518-5.pdf | 1.11 MB | Adobe PDF | ![]() Öffnen/Anzeigen |