Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/117556
Title: Modelling the public health impact of MenACWY and MenC adolescent vaccination strategies in Germany
Author(s): Gruhn, Sebastian
Batram, ManuelLook up in the Integrated Authority File of the German National Library
Wick, Moritz
Langevin, Edith
Scholz, StefanLook up in the Integrated Authority File of the German National Library
Greiner, WolfgangLook up in the Integrated Authority File of the German National Library
Damm, Oliver SiegfriedLook up in the Integrated Authority File of the German National Library
Issue Date: 2024
Type: Article
Language: English
Abstract: Introduction: Invasive meningococcal disease (IMD) causes significant mortality and long-term sequelae. This study assesses the potential public health impact of adolescent vaccination strategies employing MenACWY and MenC vaccines in Germany, where the existing meningococcal immunisation programme predominantly involves MenC administration in toddlers. Methods: A dynamic transmission model was developed to simulate the carriage of five meningococcal serogroup compartments (AY/B/C/W/ Other) from 2019 until 2060 within 1-year age groups from 0 to 99 years of age. IMD cases were estimated based on case-carrier ratios. The model considered vaccine effectiveness against carriage acquisition and IMD. Results: The model predicts that introducing MenACWY adolescent vaccination could lead to a considerable reduction in IMD incidence, with the potential to prevent up to 65 cases per year and a cumulative total of 1467 cases by 2060. This decrease, mainly driven by herd effects, would result in a reduction of IMD incidence across all age groups, regardless of vaccination age. Furthermore, implementing MenACWY vaccination in adolescents is projected to decrease annual MenACWY-related IMD mortality by up to 64%, equating to an overall prevention of 156 IMD deaths by 2060. These protective outcomes are expected to culminate in approximately 2250 life years gained (LYG) throughout the model’s projected time horizon. In contrast, the adoption of MenC vaccination in adolescents is predicted to have minimal influence on both IMD incidence and mortality, as well as on LYG. Conclusion: The results of this study demonstrate that implementing MenACWY vaccination for adolescents in Germany is likely to notably reduce IMD incidence and mortality across age groups. However, the introduction of MenC adolescent vaccination shows only limited impact. Considering the extensive healthcare resources typically required for IMD management, these findings suggest the potential for economic benefits associated with the adoption of MenACWY adolescent vaccination, warranting further cost-effectiveness analysis.
URI: https://opendata.uni-halle.de//handle/1981185920/119515
http://dx.doi.org/10.25673/117556
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Infectious diseases and therapy
Publisher: Springer
Publisher Place: Heidelberg
Volume: 13
Issue: 4
Original Publication: 10.1007/s40121-024-00958-7
Page Start: 907
Page End: 920
Appears in Collections:Open Access Publikationen der MLU

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