Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen: http://dx.doi.org/10.25673/118193
Titel: CSF synaptic biomarkers and cognitive impairment in multiple sclerosis
Autor(en): Barba, Lorenzo
Gaetani, Lorenzo
Sperandei, Silvia
Di Sabatino, Elena
Abu Rumeileh, SamirIn der Gemeinsamen Normdatei der DNB nachschlagen
Halbgebauer, SteffenIn der Gemeinsamen Normdatei der DNB nachschlagen
Oeckl, PatrickIn der Gemeinsamen Normdatei der DNB nachschlagen
Steinacker, PetraIn der Gemeinsamen Normdatei der DNB nachschlagen
Parnetti, Lucilla
Di FIlippo, Massimiliano
Otto, MarkusIn der Gemeinsamen Normdatei der DNB nachschlagen
Erscheinungsdatum: 2025
Art: Artikel
Sprache: Englisch
Zusammenfassung: Background: People with multiple sclerosis (PwMS) experience various degrees of cognitive impairment (CI). Synaptic dysfunction may contribute to CI in PwMS but cerebrospinal fluid (CSF) synaptic biomarkers are unexplored in MS. Objective: To assess the role of CSF synaptosomal-associated protein 25 (SNAP-25), β-synuclein, neurogranin and neurofilament light chain protein (NfL) in patients with early relapsing MS with and without CI. Methods: We measured CSF SNAP-25, β-synuclein, and neurogranin in 48 untreated PwMS and 50 controls with other neurological diseases (ONDs) and tested their associations with neuropsychological and MRI data. Results: CSF synaptic protein levels did not discriminate between MS subjects and patients with ONDs, with only SNAP-25 values being slightly increased in MS (p = 0.009). CSF synaptic markers were positively correlated with each other and with CSF NfL. Moreover, lower biomarker levels were found to be correlated with longer disease duration and lower brain volumes (especially of the thalamus). Moreover, we found significantly lower CSF SNAP-25 (p = 0.025), β-synuclein (p = 0.044), and neurogranin (p = 0.007) levels in PwMS with vs. without domain-specific cognitive impairment. Conclusion: Lower CSF synaptic biomarker levels were found in PwMS with longer disease duration and lower brain volumes and may identify PwMS at risk of CI.
URI: https://opendata.uni-halle.de//handle/1981185920/120152
http://dx.doi.org/10.25673/118193
Open-Access: Open-Access-Publikation
Nutzungslizenz: (CC BY 4.0) Creative Commons Namensnennung 4.0 International(CC BY 4.0) Creative Commons Namensnennung 4.0 International
Journal Titel: Journal of neurology
Verlag: Steinkopff
Verlagsort: [Darmstadt]
Band: 272
Originalveröffentlichung: 10.1007/s00415-024-12851-x
Enthalten in den Sammlungen:Open Access Publikationen der MLU

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
s00415-024-12851-x.pdf2.01 MBAdobe PDFMiniaturbild
Öffnen/Anzeigen