Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/118616
Title: Neuronal loss of the nucleus basalis of Meynert in primary progressive aphasia is associated with Alzheimer's disease neuropathological changes
Author(s): Schaeverbeke, Jolien
Tomé, Sandra O.
Ronisz, Alicja
Arnim, ChristineLook up in the Integrated Authority File of the German National Library
Otto, MarkusLook up in the Integrated Authority File of the German National Library
Vandenberghe, RikLook up in the Integrated Authority File of the German National Library
Thal, DietmarLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Introduction: Imaging studies indicated basal forebrain reduction in primary progres- sive aphasia (PPA), which might be a candidate marker for cholinergic treatment. Nucleus basalis of Meynert (nbM) neuronal loss has been reported, but a systematic quantitative neuropathological assessment including the three clinical PPA variants is lacking. Methods: Quantitative assessment of neuronal density and pathology was performed on nbM tissue of 47 cases: 15 PPA, constituting the different clinicopathological phenotypes, 14 Alzheimer’s disease (AD), and 18 cognitively normals. Results: Group-wise, reduced nbM neuronal density was restricted to AD. At the individual level, semantic variant PPA with underlying AD neuropathological change (ADNC) had lower neuronal densities, while those with frontotemporal lobar degen- eration (FTLD) transactive response DNA binding protein 43 kDa (TDP-43) type C pathology were unaffected. Higher Braak stages and increased numbers of nbM- related pretangles were associated with nbM neuronal loss. Discussion: nbM neuronal loss in PPA is related to ADNC. This study cautions against overinterpreting MRI-based basal forebrain volumes in non-AD PPA as neuronal loss.
URI: https://opendata.uni-halle.de//handle/1981185920/120574
http://dx.doi.org/10.25673/118616
Open Access: Open access publication
License: (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0(CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0
Journal Title: Alzheimer's & dementia. Diagnosis, assessment & disease monitoring
Publisher: Wiley
Publisher Place: Hoboken, NJ
Volume: 19
Issue: 4
Original Publication: 10.1002/alz.12794
Page Start: 1440
Page End: 1451
Appears in Collections:Open Access Publikationen der MLU