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Titel: Sepsis Diagnostics: Intensive Care Scoring Systems Superior to MicroRNA Biomarker Testing
Autor(en): Schumann, Julia
Link, Fabian
Krohn, Knut
Burgdorff, Anna-Maria
Christel, Annett
Körperschaft: Martin-Luther-Universität Halle-Wittenberg
Erscheinungsdatum: 2020-09-16
Art: Artikel
Sprache: Englisch
Herausgeber: Universitäts- und Landesbibliothek Sachsen-Anhalt
Schlagwörter: sepsis
inflammation
biomarker
sequential organ failure assessment (SOFA) score
miRNA
cytokines
Zusammenfassung: Sepsis represents a serious medical problem accounting for numerous deaths of critically ill patients in intensive care units (ICUs). An early, sensitive, and specific diagnosis is considered a key element for improving the outcome of sepsis patients. In addition to classical laboratory markers, ICU scoring systems and serum miRNAs are discussed as potential sepsis biomarkers. In the present prospective observational study, the suitability of miRNAs in sepsis diagnosis was tested based on proper validated and normalized data (i.e., absolute quantification by means of Droplet Digital PCR (ddPCR)) in direct comparison to classical sepsis markers and ICU scores within the same patient cohort. Therefore, blood samples of septic intensive care patients (n = 12) taken at day of admission at ICU were compared to non-septic intensive care patients (n = 12) and a healthy control group (n = 12). Our analysis indicates that all tested biomarkers have only a moderate informative power and do not allow an unequivocal differentiation between septic and non-septic ICU patients. In conclusion, there is no standalone laboratory parameter that enables a reliable diagnosis of sepsis. miRNAs are not superior to classical parameters in this respect. It seems recommendable to measure multiple parameters and scores and to interpret them with regard to the clinical presentation.
URI: https://opendata.uni-halle.de//handle/1981185920/35086
http://dx.doi.org/10.25673/34886
Open-Access: Open-Access-Publikation
Nutzungslizenz: (CC BY 4.0) Creative Commons Namensnennung 4.0 International(CC BY 4.0) Creative Commons Namensnennung 4.0 International
Originalveröffentlichung: 10.3390/diagnostics10090701
Enthalten in den Sammlungen:Medizinische Fakultät MLU

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