Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/34963
Title: A mathematical model of white blood cell dynamics during maintenance therapy of childhood acute lymphoblastic leukemia
Author(s): Le, Thuy Thi-Thien
Jost, Felix
Raupach, Thomas
Zierk, Jakob
Rauh, Manfred
Suttorp, Meinolf
Stanulla, Martin
Metzler, Markus
Sager, Sebastian
Issue Date: 2020
Extent: 1 Online-Ressource (17 Seiten, 32,59 MB)
Type: Article
Language: English
Publisher: Oxford University Press, Oxford
URN: urn:nbn:de:gbv:ma9:1-1981185920-351653
Subjects: Childhood acute lymphoblastic leukemia
Chemotherapy
Maintenance therapy
ordinary differential equations
Abstract: Acute lymphoblastic leukemia is the most common malignancy in childhood and requires prolonged oral maintenance chemotherapy to prevent disease relapse after remission induction with intensive intravenous chemotherapy. In maintenance therapy, drug doses of 6-mercaptopurine (6-MP) and methotrexate (MTX) are adjusted to achieve sustained antileukemic activity without excessive myelosuppression. However, uncertainty exists regarding timing and extent of drug dose responses and optimal dose adaptation strategies.We propose a novel comprehensive mathematical model for 6-MP and MTX pharmacokinetics, pharmacodynamics and myelosuppression in acute lymphoblastic maintenance therapy. We personalize and cross-validate the mathematical model using clinical data and propose a real-time algorithm to predict chemotherapy responses with a clinical decision support system as a potential future application.
URI: https://opendata.uni-halle.de//handle/1981185920/35165
http://dx.doi.org/10.25673/34963
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Mathematical medicine and biology
Publisher: Oxford University Press
Publisher Place: Oxford
Volume: 36
Issue: 4
Original Publication: 10.1093/imammb/dqy017
Page Start: 471
Page End: 488
Appears in Collections:Fakultät für Mathematik (OA)

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