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Title: Mathematical modeling of RBC count dynamics after blood loss
Author(s): Tetschke, Manuel
Lilienthal, Patrick
Pottgiesser, Torben
Fischer, Thomas
Schalk, EnricoLook up in the Integrated Authority File of the German National Library
Sager, SebastianLook up in the Integrated Authority File of the German National Library
Issue Date: 2020
Extent: 1 Online-Ressource (29 Seiten, 1,2 MB)
Type: Article
Language: English
Publisher: MDPI, Basel
URN: urn:nbn:de:gbv:ma9:1-1981185920-352196
Subjects: Erythropoiesis
Parameter estimation
Numerical simulation
Abstract: The regeneration of red blood cells (RBCs) after blood loss is an individual complex process. We present a novel simple compartment model which is able to capture the most important features and can be personalized using parameter estimation. We compare predictions of the proposed and personalized model to a more sophisticated state-of-the-art model for erythropoiesis, and to clinical data from healthy subjects. We discuss the choice of model parameters with respect to identifiability. We give an outlook on how extensions of this novel mathematical model could have an important impact for personalized clinical decision support in the case of polycythemia vera (PV). PV is a slow-growing type of blood cancer, where especially the production of RBCs is increased. The principal treatment targeting the symptoms of PV is bloodletting (phlebotomy), at regular intervals that are based on personal experiences of the physicians. Model-based decision support might help to identify optimal and individualized phlebotomy schedules.
Open Access: Open access publication
License: (CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0(CC BY-SA 4.0) Creative Commons Attribution ShareAlike 4.0
Journal Title: Processes
Publisher: MDPI
Publisher Place: Basel, Switzerland
Volume: 5
Issue: 9
Original Publication: 10.3390/pr6090157
Page Start: 1
Page End: 29
Appears in Collections:Fakultät für Mathematik (OA)

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