Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/36454
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dc.contributor.authorTony, Schultz-
dc.contributor.authorBock, Jörg-
dc.contributor.authorBraun, Anna Katharina-
dc.date.accessioned2021-04-29T10:10:48Z-
dc.date.available2021-04-29T10:10:48Z-
dc.date.issued2020-
dc.date.submitted2020-
dc.identifier.urihttps://opendata.uni-halle.de//handle/1981185920/36686-
dc.identifier.urihttp://dx.doi.org/10.25673/36454-
dc.description.abstractIn most mammalian species parent-offspring interactions during early life periods primarily comprise social contacts with the mother, whereas the role of males in parental care is one of the most overlooked and understudied topics. The present study addressed the hypothesis that the complete deprivation of paternal care delays or permanently retards synaptic connectivity in the brain, particularly in the medial prefrontal cortex (mPFC) of the offspring in a sex-specific manner. Another aim of this study was to address the question whether and in which way replacing the father with a female caregiver (in our experiments the “aunt”) can “buffer” the detrimental effects of paternal deprivation on neuronal development. The comparison of: (a) single mother rearing; (b) biparental rearing by father and mother; and (c) biparental rearing by two female caregivers revealed that: (i) paternal care represents a critical environmental factor for synaptic and dendritic development of pyramidal neurons in the vmPFC of their offspring; (ii) a second female caregiver (“aunt”) does not “buffer” the neuronal consequences of paternal deprivation; and that (iii) neuronal development in the vmPFC is differentially affected in male and female offspring in response to different family constellations.eng
dc.description.sponsorshipDFG-Publikationsfonds 2020-
dc.language.isoeng-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectDendritic spineseng
dc.subjectPrefrontal cortexeng
dc.subjectPaternal deprivationeng
dc.subjectFamily structureeng
dc.subjectSex differenceeng
dc.subjectPyramidal neuroneng
dc.subject.ddc570-
dc.titlePaternal deprivation and female biparental family rearing induce dendritic and synaptic changes in octodon degus : I. Medial prefrontal cortexeng
dc.typeArticle-
dc.identifier.urnurn:nbn:de:gbv:ma9:1-1981185920-366865-
local.versionTypepublishedVersion-
local.bibliographicCitation.journaltitleFrontiers in synaptic neuroscience-
local.bibliographicCitation.volume12-
local.bibliographicCitation.issue2020-
local.bibliographicCitation.pagestart1-
local.bibliographicCitation.pageend12-
local.bibliographicCitation.publishernameFrontiers Research Foundation-
local.bibliographicCitation.publisherplaceLausanne-
local.bibliographicCitation.doi10.3389/fnsyn.2020.00038-
local.openaccesstrue-
dc.identifier.ppn1738660516-
local.bibliographicCitation.year2020-
cbs.sru.importDate2021-04-29T10:06:16Z-
local.bibliographicCitationEnthalten in Frontiers in synaptic neuroscience - Lausanne : Frontiers Research Foundation, 2009-
local.accessrights.dnbfree-
Appears in Collections:Fakultät für Naturwissenschaften (OA)

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