Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/37548
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dc.contributor.authorSimon, Frieder-
dc.contributor.authorBork, Kaya-
dc.contributor.authorGnanapragassam, Vinayaga S.-
dc.contributor.authorBaldensperger, Tim-
dc.contributor.authorGlomb, Marcus A.-
dc.contributor.authorSanzo, Simone-
dc.contributor.authorOri, Alessandro-
dc.contributor.authorHorstkorte, Rüdiger-
dc.date.accessioned2021-07-29T09:07:11Z-
dc.date.available2021-07-29T09:07:11Z-
dc.date.issued2019-
dc.identifier.urihttps://opendata.uni-halle.de//handle/1981185920/37791-
dc.identifier.urihttp://dx.doi.org/10.25673/37548-
dc.description.abstractAging represents the accumulation of changes in an individual over time, encompassing physical, psychological, and social changes. Posttranslational modifications of proteins such as glycosylation, including sialylation or glycation, are proposed to be involved in this process, since they modulate a variety of molecular and cellular functions. In this study, we analyzed selected posttranslational modifications and the respective proteins on which they occur in young and old mouse brains. The expression of neural cell adhesion molecule (NCAM), receptor for advanced glycation endproducts (RAGE), as well as the carbohydrate-epitopes paucimannose and high-mannose, polysialic acid, and O-GlcNAc were examined. We demonstrated that mannose-containing glycans increased on glycoproteins in aged mouse brains and identified synapsin-1 as one major carrier of paucimannose in aged brains. In addition, we found an accumulation of so-called advanced glycation endproducts, which are generated by non-enzymatic reactions and interfere with protein function. Furthermore, we analyzed the expression of sialic acid and found also an increase during aging.eng
dc.description.sponsorshipPublikationsfond MLU-
dc.language.isoeng-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc540-
dc.titleIncreased expression of immature mannose-containing glycoproteins and sialic acid in aged mouse brainseng
dc.typeArticle-
local.versionTypepublishedVersion-
local.bibliographicCitation.journaltitleInternational journal of molecular sciences-
local.bibliographicCitation.volume20-
local.bibliographicCitation.issue24-
local.bibliographicCitation.publishernameMDPI-
local.bibliographicCitation.publisherplaceBasel-
local.bibliographicCitation.doi10.3390/ijms20246118-
local.openaccesstrue-
dc.identifier.ppn1685688519-
local.bibliographicCitation.year2019-
cbs.sru.importDate2021-07-29T09:05:46Z-
local.bibliographicCitationEnthalten in International journal of molecular sciences - Basel : Molecular Diversity Preservation International, 2000-
local.accessrights.dnbfree-
Appears in Collections:Open Access Publikationen der MLU

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