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http://dx.doi.org/10.25673/37778
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DC Element | Wert | Sprache |
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dc.contributor.author | Medenwald, Daniel | - |
dc.contributor.author | Vordermark, Dirk | - |
dc.contributor.author | Dietzel, Christian T. | - |
dc.date.accessioned | 2021-08-05T12:38:38Z | - |
dc.date.available | 2021-08-05T12:38:38Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/38021 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/37778 | - |
dc.description.abstract | Objective: To assess the extent of early mortality and its temporal course after prostatectomy and radiotherapy in the general population. Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database and East German epidemiologic cancer registries were used for the years 2005–2013. Metastasized cases were excluded. Analyzing overall mortality, year-specific Cox regression models were used after adjusting for age (including age squared), risk stage, and grading. To estimate temporal hazards, we computed year-specific conditional hazards for surgery and radiotherapy after propensity-score matching and applied piecewise proportional hazard models. Results: In German and US populations, we observed higher initial 3-month mortality odds for prostatectomy (USA: 9.4, 95% CI: 7.8–11.2; Germany: 9.1, 95% CI: 5.1–16.2) approaching the null effect value not before 24-months (estimated annual mean 36-months in US data) after diagnosis. During the observational period, we observed a constant hazard ratio for the 24-month mortality in the US population (2005: 1.7, 95% CI: 1.5–1.9; 2013: 1.9, 95% CI: 1.6–2.2) comparing surgery and radiotherapy. The same was true in the German cohort (2005: 1.4, 95% CI: 0.9–2.1; 2013: 3.3, 95% CI: 2.2–5.1). Considering low-risk cases, the adverse surgery effect appeared stronger. Conclusion: There is strong evidence from two independent populations of a considerably higher early to midterm mortality after prostatectomy compared to radiotherapy extending the time of early mortality considered by previous studies up to 36-months. | eng |
dc.description.sponsorship | Publikationsfond MLU | - |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 610 | - |
dc.title | Early mortality of prostatectomy vs. radiotherapy as a primary treatment for prostate cancer : a population-based study from the United States and East Germany | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Radiotherapy and oncology | - |
local.bibliographicCitation.volume | 9 | - |
local.bibliographicCitation.issue | 1451 | - |
local.bibliographicCitation.publishername | Elsevier Science | - |
local.bibliographicCitation.publisherplace | Amsterdam [u.a.] | - |
local.bibliographicCitation.doi | 10.3389/fonc.2019.01451 | - |
local.subject.keywords | early mortality, prostate cancer, prostatectomy, radiotherapy, general population | - |
local.openaccess | true | - |
dc.identifier.ppn | 1691908703 | - |
local.bibliographicCitation.year | 2020 | - |
cbs.sru.importDate | 2021-08-05T12:37:52Z | - |
local.bibliographicCitation | Enthalten in Radiotherapy and oncology - Amsterdam [u.a.] : Elsevier Science, 1983 | - |
local.accessrights.dnb | free | - |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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fonc-09-01451.pdf | 2.68 MB | Adobe PDF | Öffnen/Anzeigen |