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Title: Ester and amide derivatives of rhodamine B exert cytotoxic effects on different human tumor cell lines
Author(s): Serbian, ImmoLook up in the Integrated Authority File of the German National Library
Hoenke, Sophie
Kraft, Oliver
Csuk, RenéLook up in the Integrated Authority File of the German National Library
Issue Date: 2020
Type: Article
Language: English
Abstract: Three esters of rhodamine B (1–3) differing in their alkyl chain lengths as well as several rhodamine B amides (4–9) were synthesized in good yields and tested for their cytotoxicity in SRB assays employing several human tumor cell lines. The rhodamine B esters were unselective but showed cytotoxicity of as low as EC50 = 0.15 ± 0.02 µM. The rhodamine B amides were slightly less cytotoxic but showed good selectivity against MCF-7 and A2780 tumor cell lines. Especially a morpholinyl derivative 4 was ~20 time more cytotoxic for MCF-7 than for nonmalignant NIH 3T3 cells.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfond MLU
Journal Title: Medicinal chemistry research
Publisher: Birkhäuser Boston
Publisher Place: Cambridge, Mass. [u.a.]
Volume: 29
Issue: 9
Original Publication: 10.1007/s00044-020-02591-8
Page Start: 1655
Page End: 1661
Appears in Collections:Open Access Publikationen der MLU

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