Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen: http://dx.doi.org/10.25673/38264
Langanzeige der Metadaten
DC ElementWertSprache
dc.contributor.authorSteven, André-
dc.contributor.authorFriedrich, Michael-
dc.contributor.authorJank, Paul-
dc.contributor.authorHeimer, Nadine-
dc.contributor.authorBudczies, Jan-
dc.contributor.authorDenkert, Carsten-
dc.contributor.authorSeliger, Barbara-
dc.date.accessioned2021-09-02T07:20:27Z-
dc.date.available2021-09-02T07:20:27Z-
dc.date.issued2020-
dc.identifier.urihttps://opendata.uni-halle.de//handle/1981185920/38507-
dc.identifier.urihttp://dx.doi.org/10.25673/38264-
dc.description.abstractAltered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target.eng
dc.description.sponsorshipPublikationsfond MLU-
dc.language.isoeng-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc610-
dc.titleWhat turns CREB on? And off? And why does it matter?eng
dc.typeArticle-
local.versionTypepublishedVersion-
local.bibliographicCitation.journaltitleCellular and molecular life sciences-
local.bibliographicCitation.volume77-
local.bibliographicCitation.issue20-
local.bibliographicCitation.pagestart4049-
local.bibliographicCitation.pageend4067-
local.bibliographicCitation.publishernameSpringer International Publishing AG-
local.bibliographicCitation.publisherplaceCham (ZG)-
local.bibliographicCitation.doi10.1007/s00018-020-03525-8-
local.subject.keywordsTranscription factor, CREB, Carcinogenesis, Prognosis, Clinical outcome-
local.openaccesstrue-
dc.identifier.ppn1728501512-
local.bibliographicCitation.year2020-
cbs.sru.importDate2021-09-02T07:19:00Z-
local.bibliographicCitationEnthalten in Cellular and molecular life sciences - Cham (ZG) : Springer International Publishing AG, 1997-
local.accessrights.dnbfree-
Enthalten in den Sammlungen:Open Access Publikationen der MLU

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
Steven2020_Article_WhatTurnsCREBOnAndOffAndWhyDoe.pdf2.14 MBAdobe PDFMiniaturbild
Öffnen/Anzeigen