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dc.contributor.authorMüller, Lisa-
dc.contributor.authorHatzfeld, Mechthild-
dc.contributor.authorKeil, René-
dc.date.accessioned2022-03-24T08:38:04Z-
dc.date.available2022-03-24T08:38:04Z-
dc.date.issued2021-
dc.identifier.urihttps://opendata.uni-halle.de//handle/1981185920/80350-
dc.identifier.urihttp://dx.doi.org/10.25673/78396-
dc.description.abstractDesmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to change cell behavior. Desmosome composition and size vary depending on tissue specific expression and differentiation state. Their constituent proteins are highly regulated by posttranslational modifications that control their function in the desmosome itself and in addition regulate a multitude of desmosome-independent functions. This review will summarize our current knowledge how signaling pathways that control epithelial shape, polarity and function regulate desmosomes and how desmosomal proteins transduce these signals to modulate cell behavior.eng
dc.description.sponsorshipPublikationsfonds MLU-
dc.language.isoeng-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc571-
dc.titleDesmosomes as signaling hubs in the regulation of cell behavioreng
dc.typeArticle-
local.versionTypepublishedVersion-
local.bibliographicCitation.journaltitleFrontiers in cell and developmental biology-
local.bibliographicCitation.volume9-
local.bibliographicCitation.publishernameFrontiers Media-
local.bibliographicCitation.publisherplaceLausanne-
local.bibliographicCitation.doi10.3389/fcell.2021.745670-
local.openaccesstrue-
local.accessrights.dnbfree-
Enthalten in den Sammlungen:Open Access Publikationen der MLU

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