Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/81342
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Brandes, Benjamin | - |
dc.contributor.author | Halz, Jan H. | - |
dc.contributor.author | Merzweiler, Kurt | - |
dc.contributor.author | Deigner, Hans-Peter | - |
dc.contributor.author | Csuk, René | - |
dc.date.accessioned | 2022-04-05T06:39:36Z | - |
dc.date.available | 2022-04-05T06:39:36Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/83297 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/81342 | - |
dc.description.abstract | Azelastine is among the most frequently used drugs; however, knowledge and solid data about its metabolites are scarcely found in literature. Thus, microsomal oxidation of azelastine is thought to produce the corresponding N-oxides, However, until now these products had never been produced in significant amounts. By oxidation of azelastine with H2O2, these N-oxides were now prepared in racemic form for the first time and were fully characterized. Their structure was additionally confirmed by a single crystal X-ray analysis. Both N-oxides were found to be non-cytotoxic in SRB assays. | eng |
dc.description.sponsorship | Publikationsfonds MLU | - |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 540 | - |
dc.title | Synthesis and structure of azelastine-N-oxides | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | Journal of molecular structure | - |
local.bibliographicCitation.volume | 1251 | - |
local.bibliographicCitation.publishername | Elsevier | - |
local.bibliographicCitation.publisherplace | New York, NY [u.a.] | - |
local.bibliographicCitation.doi | 10.1016/j.molstruc.2021.132033 | - |
local.openaccess | true | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0022286021021530-main.pdf | 1.29 MB | Adobe PDF | View/Open |