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Title: Hemolytic performance in two generations of the sputnik left ventricular assist device : a combined numerical and experimental study
Author(s): Romanova, Alexandra N.
Pugovkin, Alexander A.
Denisov, Maxim V.
Ephimov, Ivan A.
Gusev, Dmitry V.
Walter, Marian
Groth, ThomasLook up in the Integrated Authority File of the German National Library
Bockeria, Olga L.
Le, Tatyana G.
Satyukova, Anna S.
Selishchev, Sergey V.
Telyshev, Dmitry V.
Issue Date: 2022
Type: Article
Language: English
Abstract: Background: Currently, left ventricular assist devices (LVADs) are a successful surgical treatment for patients with end-stage heart failure on the waiting list or with contraindicated heart transplantation. In Russia, Sputnik 1 LVAD was also successfully introduced into clinical practice as a bridge-to-transplant and a destination therapy device. Development of Sputnik 2 LVAD was aimed at miniaturization to reduce invasiveness, optimize hemocompatibility, and improve versatility for patients of various sizes. Methods: We compared hemolysis level in flow path of the Sputnik LVADs and investigated design aspects influencing other types of blood damage, using predictions of computational fluid dynamics (CFD) and experimental assessment. The investigated operating point was a flow rate of 5 L/min and a pressure head of 100 mm Hg at an impeller rotational speed of 9100 min−1. Results: Mean hemolysis indices predicted with CFD were 0.0090% in the Sputnik 1 and 0.0023% in the Sputnik 2. Averaged values of normalized index of hemolysis obtained experimentally for the Sputnik 1 and the Sputnik 2 were 0.011 ± 0.003 g/100 L and 0.004 ± 0.002 g/100 L, respectively. Conclusions: Obtained results indicate obvious improvements in hemocompatibility and sufficiently satisfy the determined miniaturization aim for the Sputnik 2 LVAD development.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Journal of applied biomaterials & functional materials
Publisher: Sage Publishing
Publisher Place: London
Volume: 13
Issue: 1
Original Publication: 10.3390/jfb13010007
Appears in Collections:Open Access Publikationen der MLU

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