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Title: Aspirin reduces ischemia-reperfusion injury induced endothelial cell damage of arterial grafts in a rodent model
Author(s): Veres, Gábor
Benke, Kálmán
Stengl, Roland
Bai, Yang
Stark, Klára Aliz
Sayour, Alex Ali
Radovits, Tamás
Loganathan, Sivakkanan
Korkmaz-Icöz, Sevil
Karck, Matthias
Szabó, Gábor
Issue Date: 2022
Type: Article
Language: English
Abstract: Long-term graft patency determines the prognosis of revascularization after coronary artery bypass grafting (CABG). Ischemia-reperfusion (I/R) injury of the graft suffered during harvesting and after implantation might influence graft patency. Aspirin, a nonsteroidal anti-inflammatory drug improves the long-term patency of vein grafts. Whether aspirin has the same effect on arterial grafts is questionable. We aimed to characterize the beneficial effects of aspirin on arterial bypass grafts in a rodent revascularization model. We gave Lewis rats oral pretreatment of either aspirin (n = 8) or saline (n = 8) for 5 days, then aortic arches were explanted and stored in cold preservation solution. The third group (n = 8) was a non-ischemia-reperfusion control. Afterwards the aortic arches were implanted into the abdominal aorta of recipient rats followed by 2 h of reperfusion. Endothelium-dependent vasorelaxation was examined with organ bath experiments. Immunohistochemical staining were carried out. Endothelium-dependent maximal vasorelaxation improved, nitro-oxidative stress and cell apoptosis decreased, and significant endothelial protection was shown in the aspirin preconditioned group, compared to the transplanted control group. Significantly improved endothelial function and reduced I/R injury induced structural damage were observed in free arterial grafts after oral administration of aspirin. Aspirin preconditioning before elective CABG might be beneficial on free arterial graft patency.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: Antioxidants
Publisher: MDPI
Publisher Place: Basel
Volume: 11
Issue: 2
Original Publication: 10.3390/antiox11020177
Appears in Collections:Open Access Publikationen der MLU

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