Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/85756
Title: | Changes in brain function during negative emotion processing in the long-term course of depression |
Author(s): | Enneking, Verena Klug, Melissa Borgers, Tiana Dohm, Katharina Grotegerd, Dominik Frankenberger, Lisa Marie Hülsmann, Carina Lemke, Hannah Meinert, Susanne Leehr, Elisabeth J. Opel, Nils Goltermann, Janik Richter, Maike Waltemate, Lena Böhnlein, Joscha Sindermann, Lisa Repple, Jonathan Bauer, Jochen Thomas, Mareike Dannlowski, Udo Redlich, Ronny |
Issue Date: | 2022 |
Type: | Article |
Language: | English |
Abstract: | Background: Relapses in major depression are frequent and are associated with a high burden of disease. Although short-term studies suggest a normalisation of depression-associated brain functional alterations directly after treatment, long-term investigations are sparse. Aims: To examine brain function during negative emotion processing in association with course of illness over a 2-year span. Method: In this prospective case–control study, 72 in-patients with current depression and 42 healthy controls were investigated during a negative emotional face processing paradigm, at baseline and after 2 years. According to their course of illness during the study interval, patients were divided into subgroups (n = 25 no-relapse, n = 47 relapse). The differential changes in brain activity were investigated by a group × time analysis of covariance for the amygdala, hippocampus, insula and at whole-brain level. Results: A significant relapse × time interaction emerged within the amygdala (PTFCE-FWE = 0.011), insula (PTFCE-FWE = 0.001) and at the whole-brain level mainly in the temporal and prefrontal cortex (PTFCE-FWE = 0.027), resulting from activity increases within the no-relapse group, whereas in the relapse group, activity decreased during the study interval. At baseline, the no-relapse group showed amygdala, hippocampus and insula hypoactivity compared with healthy controls and the relapse group. Conclusions: This study reveals course of illness-associated activity changes in emotion processing areas. Patients in full remission show a normalisation of their baseline hypo-responsiveness to the activation level of healthy controls after 2 years. Brain function during emotion processing could further serve as a potential predictive marker for future relapse. |
URI: | https://opendata.uni-halle.de//handle/1981185920/87708 http://dx.doi.org/10.25673/85756 |
Open Access: | Open access publication |
License: | (CC BY 4.0) Creative Commons Attribution 4.0 |
Sponsor/Funder: | Publikationsfonds MLU |
Journal Title: | The British journal of psychiatry |
Publisher: | Cambridge University Press |
Publisher Place: | Cambridge |
Original Publication: | 10.1192/bjp.2021.223 |
Appears in Collections: | Open Access Publikationen der MLU |
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changes-in-brain-function-during-negative-emotion-processing-in-the-long-term-course-of-depression.pdf | 623.15 kB | Adobe PDF | View/Open |