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Title: Trifluoromethylated 3‐(Pyrazol‐1‐yl)propanamide (PPA) ligands
Author(s): Liebing, Phil
Edelmann, Frank T.Look up in the Integrated Authority File of the German National Library
Issue Date: 2020
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-878470
Subjects: Pyrazole ligands
Fluorinated ligands
Palladium complexes
X-ray structure elucidation
Hydrogen bonds
Abstract: The new PPA ligands 3-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]propanamide (CF3MePPA; 3) and 3-[3,5- bis(trifluoromethyl)-1H-pyrazol-1-yl]propanamide ((CF3)2PPA; 4) were synthesized by Aza-Michael addition of the specific pyrazole derivatives to acrylamide. Both products were characterized by elemental analyses, IR and NMR spectroscopy, and mass spectrometry. X-Ray structure determination of 3 revealed the presence of a onedimensional hydrogen-bonded structure in the solid state. The ligating ability of the new ligands towards PdCl2 was studied, showing that 3 behaves similar to Me2PPA and reacts cleanly with PdCl2 to afford the sparingly soluble complex PdCl2(CF3MePPA-кN)2. By contrast, the donor ability of pyrazolyl group in 4 was found to be considerably reduced, thus resulting in the formation of the unusual complex PdCl2{(CF3)2PPA-кN}{(CF3)2PPA-кO}.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Projekt DEAL 2020
Journal Title: Helvetica chimica acta
Publisher: Wiley-VCH
Publisher Place: New York, NY
Volume: 103
Issue: 10
Original Publication: 10.1002/hlca.202000148
Page Start: 1
Page End: 5
Appears in Collections:Fakultät für Naturwissenschaften (OA)

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