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http://dx.doi.org/10.25673/85903
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DC Field | Value | Language |
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dc.contributor.author | Bailer, Anja C. | - |
dc.contributor.author | Philipp, Sophie | - |
dc.contributor.author | Staudt, Shabnam | - |
dc.contributor.author | Weidauer, Thomas | - |
dc.contributor.author | Kiehntopf, Michael | - |
dc.contributor.author | Lorkowski, Stefan | - |
dc.contributor.author | Stangl, Gabriele I. | - |
dc.contributor.author | Dawczynski, Christine | - |
dc.date.accessioned | 2022-05-19T06:17:39Z | - |
dc.date.available | 2022-05-19T06:17:39Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://opendata.uni-halle.de//handle/1981185920/87856 | - |
dc.identifier.uri | http://dx.doi.org/10.25673/85903 | - |
dc.description.abstract | Purpose: This study investigated whether UVB-exposed wheat germ oil (WGO) is capable to improving the vitamin D status in healthy volunteers. Methods: A randomized controlled human-intervention trial in parallel design was conducted in Jena (Germany) between February and April. Ultimately, 46 healthy males and females with low mean 25-hydroxyvitamin D (25(OH)D) levels (34.9 ± 10.6 nmol/L) were randomized into three groups receiving either no WGO oil (control, n = 14), 10 g non-exposed WGO per day (– UVB WGO, n = 16) or 10 g WGO, which was exposed for 10 min to ultraviolet B-light (UVB, intensity 500–630 µW/cm2) and provided 23.7 µg vitamin D (22.9 µg vitamin D2 and 0.89 µg vitamin D3) (+ UVB WGO, n = 16) for 6 weeks. Blood was obtained at baseline, after 3 and 6 weeks and analyzed for serum vitamin D-metabolite concentrations via LC–MS/MS. Results: Participants who received the UVB-exposed WGO were characterized by an increase of circulating 25(OH)D2 after 3 and 6 weeks of intervention. However, the 25(OH)D3 concentrations decreased in the + UVB WGO group, while they increased in the control groups. Finally, the total 25(OH)D concentration (25(OH)D2 + 25(OH)D3) in the + UVB WGO group was lower than that of the non-WGO receiving control group after 6 weeks of treatment. In contrast, circulating vitamin D (vitamin D2 + vitamin D3) was higher in the + UVB WGO group than in the control group receiving no WGO. Conclusion: UVB-exposed WGO containing 23.7 µg vitamin D can increase 25(OH)D2 levels but do no improve total serum levels of 25(OH)D of vitamin D-insufficient subjects. | eng |
dc.description.sponsorship | Publikationsfonds MLU | - |
dc.language.iso | eng | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.subject.ddc | 613 | - |
dc.title | UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D2 without improving overall vitamin D status : a randomized controlled trial | eng |
dc.type | Article | - |
local.versionType | publishedVersion | - |
local.bibliographicCitation.journaltitle | European journal of nutrition | - |
local.bibliographicCitation.publishername | Steinkopff | - |
local.bibliographicCitation.publisherplace | Darmstadt | - |
local.bibliographicCitation.doi | 10.1007/s00394-022-02827-w | - |
local.openaccess | true | - |
local.accessrights.dnb | free | - |
Appears in Collections: | Open Access Publikationen der MLU |
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File | Description | Size | Format | |
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Bailer2022_Article_UVB-exposedWheatGermOilIncreas.pdf | 814.8 kB | Adobe PDF | ![]() View/Open |