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Title: Dietary protein intake and health-related outcomes : a methodological protocol for the evidence evaluation and the outline of an evidence to decision framework underlying the evidence-based guideline of the German Nutrition Society
Author(s): Kroke, Anja
Schmidt, Annemarie
Amini, Anna M.
Kalotai, Nicole
Lehmann, Andreas
Haardt, Julia
Bauer, Jürgen M.
Bischoff-Ferrari, Heike A.
Boeing, Heiner
Egert, Sarah
Ellinger, Sabine
Kühn, Tilman
Louis, Sandrine
Lorkowski, Stefan
Nimptsch, Katharina
Remer, Thomas
Schulze, Matthias B.
Siener, Roswitha
Stangl, Gabriele I.
Volkert, Dorothee
Zittermann, Armin
Buyken, Anette E.
Watzl, Bernhard
Schwingshackl, Lukas
Issue Date: 2022
Type: Article
Language: English
Abstract: Purpose: The present work aimed to delineate (i) a revised protocol according to recent methodological developments in evidence generation, to (ii) describe its interpretation, the assessment of the overall certainty of evidence and to (iii) outline an Evidence to Decision framework for deriving an evidence-based guideline on quantitative and qualitative aspects of dietary protein intake. Methods: A methodological protocol to systematically investigate the association between dietary protein intake and several health outcomes and for deriving dietary protein intake recommendations for the primary prevention of various non-communicable diseases in the general adult population was developed. Results: The developed methodological protocol relies on umbrella reviews including systematic reviews with or without meta-analyses. Systematic literature searches in three databases will be performed for each health-related outcome. The methodological quality of all selected systematic reviews will be evaluated using a modified version of AMSTAR 2, and the outcome-specific certainty of evidence for systematic reviews with or without meta-analysis will be assessed with NutriGrade. The general outline of the Evidence to Decision framework foresees that recommendations in the derived guideline will be given based on the overall certainty of evidence as well as on additional criteria such as sustainability. Conclusion: The methodological protocol permits a systematic evaluation of published systematic reviews on dietary protein intake and its association with selected health-related outcomes. An Evidence to Decision framework will be the basis for the overall conclusions and the resulting recommendations for dietary protein intake.
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Publikationsfonds MLU
Journal Title: European journal of nutrition
Publisher: Steinkopff
Publisher Place: Darmstadt
Volume: 61
Original Publication: 10.1007/s00394-021-02789-5
Page Start: 2091
Page End: 2101
Appears in Collections:Open Access Publikationen der MLU

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