Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/101735| Title: | Converting bile acids into mitocans |
| Author(s): | Brandes, Benjamin Hoenke, Sophie Schultz, Christian Deigner, Hans-Peter  Csuk, René |
| Issue Date: | 2023 |
| Type: | Article |
| Language: | English |
| Abstract: | Cholic acid (1, CD), deoxycholic (3, DCA), chenodeoxycholic acid (5, CDCA), ursodeoxycholic acid (7, UDCA), and lithocholic acid (9, LCA) were acetylated and converted into their piperazinyl spacered rhodamine B conjugates 16–20. While the parent bile acids showed almost no cytotoxic effects for several human tumor cell lines, the piperazinyl amides were cytostatic but an even superior effect was observed for the rhodamine B conjugates. Extra staining experiments showed these compounds as mitocans; they led to a cell arrest in the G1 phase. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/103682 http://dx.doi.org/10.25673/101735 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Journal Title: | Steroids |
| Publisher: | Elsevier Science |
| Publisher Place: | Amsterdam [u.a.] |
| Volume: | 189 |
| Original Publication: | 10.1016/j.steroids.2022.109148 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S0039128X22001878-main.pdf | 3.91 MB | Adobe PDF |  View/Open |