Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/101735
Title: Converting bile acids into mitocans
Author(s): Brandes, Benjamin
Hoenke, Sophie
Schultz, Christian
Deigner, Hans-PeterLook up in the Integrated Authority File of the German National Library
Csuk, RenéLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Cholic acid (1, CD), deoxycholic (3, DCA), chenodeoxycholic acid (5, CDCA), ursodeoxycholic acid (7, UDCA), and lithocholic acid (9, LCA) were acetylated and converted into their piperazinyl spacered rhodamine B conjugates 16–20. While the parent bile acids showed almost no cytotoxic effects for several human tumor cell lines, the piperazinyl amides were cytostatic but an even superior effect was observed for the rhodamine B conjugates. Extra staining experiments showed these compounds as mitocans; they led to a cell arrest in the G1 phase.
URI: https://opendata.uni-halle.de//handle/1981185920/103682
http://dx.doi.org/10.25673/101735
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Steroids
Publisher: Elsevier Science
Publisher Place: Amsterdam [u.a.]
Volume: 189
Original Publication: 10.1016/j.steroids.2022.109148
Appears in Collections:Open Access Publikationen der MLU

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