Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/101905
Title: | The impact of brain lesions on health-related quality of life in patients with WHO CNS grade 3 or 4 glioma : a lesion-function and resting-state fMRI analysis |
Author(s): | Heinzel, Alexander Mottaghy, Felix Filß, Christian Stoffels, Gabriele Lohmann, Philipp Friedrich, Michel Shah, Nadim Jon Caspers, Svenja Inga Verena Weiß Lucas, Carolin Ruge, Maximilian Ingolf Galldiks, Norbert Fink, Gereon R. Langen, Karl-Josef Kocher, Martin |
Issue Date: | 2023 |
Type: | Article |
Language: | English |
Abstract: | Purpose: In glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect HRQoL. Methods: In 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained. Resection cavities, T1-enhancing lesions, T2/FLAIR hyperintensities, and lesions with pathologically increased FET uptake were delineated. Effects of tumor lateralization, involvement of white matter tracts or resting-state network nodes by different types of lesions and within-network rs-fMRI connectivity were analyzed in terms of their interaction with HRQoL scores. Results: Right hemisphere gliomas were associated with significantly less favorable outcomes in physical, role, emotional and social functioning, compared with left-sided tumors. Most functional HRQoL scores correlated significantly with right-sided white-matter tracts involvement by T2/FLAIR hyperintensities and with loss of within-network functional connectivity of right-sided nodes. Tumors of the left hemisphere caused significantly more communication deficits. Conclusion: In pretreated high-grade gliomas, right hemisphere lesions are associated with reduced HRQoL scores in most functional domains except communication ability, compared to tumors of the left hemisphere. These relationships are mainly observed for T2/FLAIR lesions involving structural and functional networks in the right hemisphere. The data suggest that sparing the right hemisphere from treatment-related tissue damage may improve HRQoL in glioma patients. |
URI: | https://opendata.uni-halle.de//handle/1981185920/103856 http://dx.doi.org/10.25673/101905 |
Open Access: | Open access publication |
License: | (CC BY 4.0) Creative Commons Attribution 4.0 |
Journal Title: | Journal of neuro-oncology |
Publisher: | Springer Science + Business Media B.V |
Publisher Place: | Dordrecht [u.a.] |
Volume: | 161 |
Original Publication: | 10.1007/s11060-023-04254-1 |
Page Start: | 643 |
Page End: | 654 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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s11060-023-04254-1.pdf | 1.46 MB | Adobe PDF | View/Open |