Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/102961
Title: No association of malignant B-cell non-Hodgkin lymphomas with ipsilateral SARS-CoV-2 vaccination
Author(s): Claaß, Luise Victoria
Mayr, PatrickLook up in the Integrated Authority File of the German National Library
Paschold, Lisa
Weber, Thomas
Terziev, DenisLook up in the Integrated Authority File of the German National Library
Jehs, Bertram
Brill, RichardLook up in the Integrated Authority File of the German National Library
Dober, Johannes
Märkl, BrunoLook up in the Integrated Authority File of the German National Library
Wickenhauser, Claudia
Czapiewski, PiotrLook up in the Integrated Authority File of the German National Library
Trepel, MartinLook up in the Integrated Authority File of the German National Library
Claus, RainerLook up in the Integrated Authority File of the German National Library
Binder, MaschaLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Purpose: SARS-CoV- 2 vaccines cause acute ipsilateral lymph node swelling in an important proportion of vaccines. Thus far, no malignant lymphadenopathies have been reported in temporal context to vaccination in the ipsilateral draining lymph node areas. Experimental design: Prompted by two cases with unilateral axillary lymphomas that occurred ipsilaterally to prior SARS-CoV- 2 vaccination, we systematically retrieved all B-cell non-Hodgkin lymphomas at two German University Medical Centers diagnosed before and after introduction of SARS-CoV- 2 vaccines in Germany. Available lymphoma tissue (n=19) was subjected to next-generation immunosequencing of the IGH locus. Malignant clonotypes were mined in the CoVabDab database and published data sets from 342 uninfected individuals, 55 individuals 28 days after anti-SARS- CoV- 2 vaccination and 139 individuals with acute COVID-19 together encompassing over 1 million CDR3 sequences in total. Results: Of 313 newly diagnosed cases in the two centers and observation periods, 27 unilateral manifestations in the defined deltoid draining regions were identified. The majority thereof were diffuse large B-cell lymphomas (18 of 27 cases). Eleven unilateral cases were diagnosed in the era of SARS-CoV- 2 vaccination and 16 in the control period before introduction of such vaccines. Of the 11 unilateral lymphomas that occurred during the vaccination period, ten had received a SARS-CoV- 2 vaccine prior to lymphoma diagnosis. These cases were further evaluated. While left-sided were more frequent than right-sided lymphomas (19 vs 8 cases), no statistically significant association of vaccination site and laterality of the lymphoma manifestation was found. The unilateral lymphomas showed a normal range of B-cell receptors typically found in these lymphoma subtypes with no evidence for anti-SARS- CoV- 2 sequences in the malignant clonotype. Conclusions: Together, we found no evidence that the current SARS-CoV- 2 vaccines could serve as a trigger for lymphomagenesis in the draining lymph node areas of the deltoid region used for vaccination.
URI: https://opendata.uni-halle.de//handle/1981185920/104914
http://dx.doi.org/10.25673/102961
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Cancer medicine
Publisher: Wiley
Publisher Place: Hoboken, NJ
Original Publication: 10.1002/cam4.5687
Appears in Collections:Open Access Publikationen der MLU