Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/103282
Title: | Is it feasible and ethical to randomize patients between surgery and non-surgical treatments for gastrointestinal cancers? |
Author(s): | Gomes dos Santos Ferreira Rebelo, Artur Luis Klose, Johannes Kleeff, Jörg H. Ronellenfitsch, Ulrich |
Issue Date: | 2023 |
Type: | Article |
Language: | English |
Abstract: | Background: In several settings in the treatment of gastrointestinal cancers, it is unclear if the addition of surgery to a multimodal treatment strategy, or in some circumstances its omission, lead to a better outcome for patients. In such situations of clinical equipoise, high-quality evidence from randomised-controlled trials is needed to decide which treatment approach is preferable. Objective: In this article, we outline the importance of randomised trials comparing surgery with non-surgical therapies for specific scenarios in the treatment of gastrointestinal cancers. We explain the difficulties and solutions of designing these trials and recruiting patients in this context. Methods: We performed a selective review based on a not systematic literature search in core databases, supplemented by browsing health information journals and citation searching. Only articles in English were selected. Based on this search, we discuss the results and methodological characteristics of several trials which randomised patients with gastrointestinal cancers between surgery and non-surgical treatments, highlighting their differences, advantages, and limitations. Results and conclusions: Innovative and effective cancer treatment requires randomised trials, also comparing surgery and non-surgical treatments for defined scenarios in the treatment of gastrointestinal malignancies. Nevertheless, potential obstacles to designing and carrying out these trials must be recognised ahead of time to avoid problems before or during the trial. |
URI: | https://opendata.uni-halle.de//handle/1981185920/105234 http://dx.doi.org/10.25673/103282 |
Open Access: | Open access publication |
License: | (CC BY 4.0) Creative Commons Attribution 4.0 |
Journal Title: | Frontiers in oncology |
Publisher: | Frontiers Media |
Publisher Place: | Lausanne |
Volume: | 13 |
Original Publication: | 10.3389/fonc.2023.1119436 |
Page Start: | 1 |
Page End: | 6 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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fonc-13-1119436.pdf | 374.34 kB | Adobe PDF | View/Open |