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http://dx.doi.org/10.25673/108835
Titel: | Glycopenia - induced sympathoadrenal activation in diabetes mellitus and uncontrolled arterial hypertension : an observational study |
Autor(en): | Abobarin-Adeagbo, Abimbola Wienke, Andreas ![]() Girndt, Matthias ![]() Pliquett, Rainer U. ![]() |
Erscheinungsdatum: | 2020 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | Background: Aim of this study is to investigate a possible association of hypoglycemic episodes and arterial hypertension. We hypothesize that hospitalized insulin-treated diabetes patients with hypertensive crisis have more hypoglycemic episodes than their counterparts without hypertensive crisis on admission. Methods: In a prospective, observational cohort study, 65 insulin-treated diabetes patients (type 1, type 2, type 3c) were included in Group 1, when a hypertensive crisis was present, as control patients in Group 2 without hypertensive crisis or hypoglycemia, in Group 3, when a symptomatic hypoglycemia was present on admission. All patients were subjected to open-label continuous glucose monitoring, 24-h blood-pressure- and Holter electrocardiogram recordings, and to laboratory tests including plasma catecholamines. Results: 53 patients, thereof 19 Group-1, 19 Group-2, 15 Group-3 patients, completed this study. Group-1 patients had the highest maximum systolic blood pressure, a higher daily cumulative insulin dose at admission, a higher body-mass index, and a higher plasma norepinephrine than control patients of Group 2. Group-3 patients had more documented hypoglycemic episodes (0.8 ± 0.5 per 24 h) than Group-2 patients (0.2 ± 0.3 per 24 h), however, they were not different to the ones in Group-1 patients (0.4 ± 0.4 per 24 h). Plasma norepinephrine and mean arterial blood pressure were higher Group-1 and Group-3 patients than in control patients of Group 2. At discharge, the daily cumulative insulin dose was reduced in Group-1 (− 18.4 ± 24.9 units) and in Group-3 patients (− 18.6 ± 22.7 units), but remained unchanged in Group-2 control patients (− 2.9 ± 15.6 units). Conclusions: An association between hypoglycemic events and uncontrolled hypertension was found in this study. |
URI: | https://opendata.uni-halle.de//handle/1981185920/110790 http://dx.doi.org/10.25673/108835 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Journal Titel: | Diabetology & metabolic syndrome |
Verlag: | BioMed Central |
Verlagsort: | London |
Band: | 12 |
Originalveröffentlichung: | 10.1186/s13098-020-00613-4 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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s13098-020-00613-4.pdf | 1.1 MB | Adobe PDF | ![]() Öffnen/Anzeigen |