Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/108835
Title: Glycopenia - induced sympathoadrenal activation in diabetes mellitus and uncontrolled arterial hypertension : an observational study
Author(s): Abobarin-Adeagbo, Abimbola
Wienke, AndreasLook up in the Integrated Authority File of the German National Library
Girndt, MatthiasLook up in the Integrated Authority File of the German National Library
Pliquett, Rainer U.Look up in the Integrated Authority File of the German National Library
Issue Date: 2020
Type: Article
Language: English
Abstract: Background: Aim of this study is to investigate a possible association of hypoglycemic episodes and arterial hypertension. We hypothesize that hospitalized insulin-treated diabetes patients with hypertensive crisis have more hypoglycemic episodes than their counterparts without hypertensive crisis on admission. Methods: In a prospective, observational cohort study, 65 insulin-treated diabetes patients (type 1, type 2, type 3c) were included in Group 1, when a hypertensive crisis was present, as control patients in Group 2 without hypertensive crisis or hypoglycemia, in Group 3, when a symptomatic hypoglycemia was present on admission. All patients were subjected to open-label continuous glucose monitoring, 24-h blood-pressure- and Holter electrocardiogram recordings, and to laboratory tests including plasma catecholamines. Results: 53 patients, thereof 19 Group-1, 19 Group-2, 15 Group-3 patients, completed this study. Group-1 patients had the highest maximum systolic blood pressure, a higher daily cumulative insulin dose at admission, a higher body-mass index, and a higher plasma norepinephrine than control patients of Group 2. Group-3 patients had more documented hypoglycemic episodes (0.8 ± 0.5 per 24 h) than Group-2 patients (0.2 ± 0.3 per 24 h), however, they were not different to the ones in Group-1 patients (0.4 ± 0.4 per 24 h). Plasma norepinephrine and mean arterial blood pressure were higher Group-1 and Group-3 patients than in control patients of Group 2. At discharge, the daily cumulative insulin dose was reduced in Group-1 (− 18.4 ± 24.9 units) and in Group-3 patients (− 18.6 ± 22.7 units), but remained unchanged in Group-2 control patients (− 2.9 ± 15.6 units). Conclusions: An association between hypoglycemic events and uncontrolled hypertension was found in this study.
URI: https://opendata.uni-halle.de//handle/1981185920/110790
http://dx.doi.org/10.25673/108835
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Diabetology & metabolic syndrome
Publisher: BioMed Central
Publisher Place: London
Volume: 12
Original Publication: 10.1186/s13098-020-00613-4
Appears in Collections:Open Access Publikationen der MLU

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