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http://dx.doi.org/10.25673/109840| Title: | Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease |
| Author(s): | Jung, Matthias Hartmann, Carla Ehrhardt, Toni  Peter, Lisa-Maria Abid, Chaudhry Luqman Harwardt, Bernadette Hirschfeld, Jana Claus, Claudia Haferkamp, Undine Pleß, Ole Nastainczyk-Wulf, Marina Kehlen, Astrid Schlote, Dietmar Schröder, Insa Sigrid Rujescu, Dan |
| Issue Date: | 2023 |
| Type: | Article |
| Language: | English |
| Abstract: | Late-onset Alzheimer disease (LOAD) is the most frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for LOAD. Four human induced pluripotent stem cell (iPSC) lines MLUi007-J, MLUi008-B, MLUi009-A, and MLUi010-B were generated from LOAD patients and healthy matched donors by reprogramming of B-lymphoblastoid cells (B-LCLs) with episomal plasmids. The application of B-LCLs holds a great promise to model LOAD and other diseases because they can easily be generated from primary peripheral blood mononuclear cells (PBMCs) by infection with the Epstein-Barr virus (EBV). |
| URI: | https://opendata.uni-halle.de//handle/1981185920/111795 http://dx.doi.org/10.25673/109840 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Journal Title: | Stem cell research |
| Publisher: | Elsevier |
| Publisher Place: | Amsterdam [u.a.] |
| Volume: | 69 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S1873506123000582-main.pdf | 5.48 MB | Adobe PDF |  View/Open |