Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/111820
Title: Significant improvement in neuropsychological functions after awake craniotomy in a patient with Oligodendroglioma : a case report
Author(s): Thomas, MareikeLook up in the Integrated Authority File of the German National Library
Scheer, Maximilian
Spindler, Kai
Nieberlein, Laura
Hartwigsen, GesaLook up in the Integrated Authority File of the German National Library
Gussew, Alexander
Schob, StefanLook up in the Integrated Authority File of the German National Library
Prell, Julian
Strauss, ChristianLook up in the Integrated Authority File of the German National Library
Rampp, StefanLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Objective: The goal of awake craniotomy in glioma patients is sparing of cognitive function. Previous investigations suggest that patients in the postoperative state may reach their preoperative level regarding domain-based criteria. Data on significant postoperative improvement beyond the preoperative level is sparse. This article examines the prospective neuropsychological assessment of a glioma patient who underwent awake craniotomy and has shown functional improvement exceeding preoperative levels. Methods: A 34-year-old patient with high premorbid cognitive function level who underwent awake craniotomy for left frontal oligodendroglioma was neuropsychologically assessed and took part in a fMRI-examination at 3 different time points. Results: Preoperative examination revealed severe isolated impairment of working memory, long-term narrative memory in free recall and recognition, and alertness with intact language production and comprehension. After transient global aphasia in the postoperative state, the follow-up examination showed significant improvement in memory and attention exceeding the preoperative level. Conclusions: Tumor location is an important factor in terms of surgical procedures. Cognitive impairment is, however, not always associated with a specific location. Mechanical pressure of the tumor might have led to the isolated consolidation deficit which fully recovered after tumor removal. Psychological disorders should be taken into account regarding prodromal symptoms of neurooncological diseases.
URI: https://opendata.uni-halle.de//handle/1981185920/113777
http://dx.doi.org/10.25673/111820
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Interdisciplinary Neurosurgery
Publisher: Elsevier
Publisher Place: Amsterdam [u.a.]
Volume: 33
Original Publication: 10.1016/j.inat.2023.101796
Appears in Collections:Open Access Publikationen der MLU

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