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http://dx.doi.org/10.25673/113662
Titel: | The interleukin 6 protein level as well as a genetic variants, (rs1800795, rs1800797) are associated with adverse cardiovascular outcomes within 10-years follow-up |
Autor(en): | Schulz, Susanne![]() Rehm, Selina Schlitt, Axel ![]() Bitter, Kerstin ![]() Reichert, Stefan ![]() |
Erscheinungsdatum: | 2023 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | Background: Worldwide, cardiovascular disease (CVD) is the leading cause of premature death. The proinflammatory cytokine interleukin 6 (IL-6) is a essential marker of innate immunity that is considered to play an important proatherogenic role for cardiovascular disease. The aim of this study (substudy of ClinTrials.gov identifier: NCT01045070) was to evaluate IL-6 protein level and genetic variants (rs1800795, rs1800797) with respect to CV outcome (combined endpoint: myocardial infarction, stroke/transient ischemic attack, cardiac death, death according to stroke) among patients CVD within 10-years follow-up. Material and methods: Overall 1002 in-patients with CVD were included. IL-6 protein level was determined by electrochemiluminescence immunoassay (fasting, between 7 and 8 a.m.). Genetic analyses were carried out by single specific primer-polymerase chain reaction. Results: In survival analyses, IL-6 protein levels of ≥6.4 pg/mL (log-rank test: p = 0.034; cox regression: p = 0.032, hazard ratio = 1.29) and CC genotype of rs1800795 (log-rank test: p < 0.001, cox regression: p < 0.001, hazard ratio = 1.72) and AA genotype of rs180797 (log-rank test: p = 0.002, cox regression: p < 0.001, hazard ratio = 1.62) were associated with a poorer CV prognosis considering combined CV endpoint. Conclusion: This study was the first to investigate both elevated IL-6 levels and genetic variants for their prognostic value for adverse CV outcomes in CVD patients within the 10-year follow-up period. |
URI: | https://opendata.uni-halle.de//handle/1981185920/115617 http://dx.doi.org/10.25673/113662 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Journal Titel: | Cells |
Verlag: | MDPI |
Verlagsort: | Basel |
Band: | 12 |
Heft: | 23 |
Originalveröffentlichung: | 10.3390/cells12232722 |
Seitenanfang: | 1 |
Seitenende: | 12 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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cells-12-02722.pdf | 2.03 MB | Adobe PDF | ![]() Öffnen/Anzeigen |