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http://dx.doi.org/10.25673/115501
Titel: | Correlation of increased soluble tumor necrosis factor receptor 1 with mortality and dependence on treatment in non-small-cell lung cancer patients : a longitudinal cohort study |
Autor(en): | Hassan, Lamiaa Bedir, Ahmed ![]() Kraus, Frank Bernhard ![]() Ostheimer, Christian ![]() Vordermark, Dirk ![]() Mikolajczyk, Rafael ![]() Seliger, Barbara ![]() Medenwald, Daniel ![]() |
Erscheinungsdatum: | 2024 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | Background: Tumor necrosis factor (TNF) is a multipotent cytokine involved in inflammation and anti-tumor activity. TNF-𝛼 exerts its function upon binding to TNF-receptor 1 (TNF-R1) and TNF-receptor 2 (TNF-R2). This study investigates the relationship of soluble (s) TNF-R1 levels in non-small-cell lung cancer (NSCLC) patients with treatment and overall survival. Methods: In total, 134 NSCLC patients treated at the Medical Faculty of Martin Luther University Halle-Wittenberg between 2017 and 2019 were included in this study. Serum levels of sTNF-R1 were measured via ELISA at baseline and during and after treatment. A linear mixed-effects model was used to assess sTNF-R1 changes over time. Linear regression was applied to investigate the association between clinical characteristics and changes in sTNF-R1. Cox regression models were used to estimate associations with overall mortality. Results: The estimated average sTNFR-1 at baseline was 2091.71 pg/mL, with a change of 6.19 pg/mL per day. Cox models revealed that the individual change in sTNF-R1 was more strongly associated with mortality than its baseline value, especially after adjusting for covariates. Conclusions: This study provides evidence that the individual change in sTNF-R1 levels during and after treatment were associated with the risk of mortality, suggesting the use of the sTNF-R1 trajectory as a prognostic marker. |
URI: | https://opendata.uni-halle.de//handle/1981185920/117455 http://dx.doi.org/10.25673/115501 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Journal Titel: | Cancers |
Verlag: | MDPI |
Verlagsort: | Basel |
Band: | 16 |
Heft: | 3 |
Originalveröffentlichung: | 10.3390/cancers16030525 |
Seitenanfang: | 1 |
Seitenende: | 10 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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cancers-16-00525-v2.pdf | 629.41 kB | Adobe PDF | ![]() Öffnen/Anzeigen |