Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/115591
Title: NANOS1 restricts oral cancer cell motility and TGF-ß signaling
Author(s): Rosemann, Julia
Pyko, Jonas
Jacob, Roland
Macho, Jana
Kappler, MatthiasLook up in the Integrated Authority File of the German National Library
Eckert, Alexander W.Look up in the Integrated Authority File of the German National Library
Hämmerle, MonikaLook up in the Integrated Authority File of the German National Library
Gutschner, TonyLook up in the Integrated Authority File of the German National Library
Issue Date: 2024
Type: Article
Language: English
Abstract: Oral squamous cell carcinoma (OSCC) is the most frequent type of cancer of the head and neck area accounting for approx. 377,000 new cancer cases every year. The epithelial-to-mesenchymal transition (EMT) program plays an important role in OSCC progression and metastasis therefore contributing to a poor prognosis in patients with advanced disease. Transforming growth factor beta (TGF-ß) is a powerful inducer of EMT thereby increasing cancer cell aggressiveness. Here, we aimed at identifying RNA-binding proteins (RBPs) that affect TGF-ß-induced EMT. To this end we treated oral cancer cells with TGF-ß and identified a total of 643 significantly deregulated protein-coding genes in response to TGF-ß. Of note, 19 genes encoded RBPs with NANOS1 being the most downregulated RBP. Subsequent cellular studies demonstrated a strong inhibitory effect of NANOS1 on migration and invasion of SAS oral cancer cells. Further mechanistic studies revealed an interaction of NANOS1 with the TGF-ß receptor 1 (TGFBR1) mRNA, leading to increased decay of this transcript and a reduced TGFBR1 protein expression, thereby preventing downstream TGF-ß/SMAD signaling. In summary, we identified NANOS1 as negative regulator of TGF-ß signaling in oral cancer cells.
URI: https://opendata.uni-halle.de//handle/1981185920/117544
http://dx.doi.org/10.25673/115591
Open Access: Open access publication
License: (CC BY-NC 4.0) Creative Commons Attribution NonCommercial 4.0(CC BY-NC 4.0) Creative Commons Attribution NonCommercial 4.0
Journal Title: European journal of cell biology
Publisher: Elsevier
Publisher Place: München
Volume: 103
Issue: 2
Original Publication: 10.1016/j.ejcb.2024.151400
Appears in Collections:Open Access Publikationen der MLU

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