Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/118268
Title: Likelihood of post-COVID condition in people with hybrid immunity : data from the German National Cohort (NAKO)
Author(s): Mikolajczyk, RafaelLook up in the Integrated Authority File of the German National Library
Diexer, Sophie
Klee, Bianca
Pfrommer, Laura
Purschke, Oliver
Fricke, JuliaLook up in the Integrated Authority File of the German National Library
Ahnert, PeterLook up in the Integrated Authority File of the German National Library
Gabrysch, SabineLook up in the Integrated Authority File of the German National Library
Gottschick, Cornelia
Bohn, BarbaraLook up in the Integrated Authority File of the German National Library
Brenner, HermannLook up in the Integrated Authority File of the German National Library
Buck, Christoph
Castell, Stefanie
Gastell, Sylvia
Greiser, Karin HalinaLook up in the Integrated Authority File of the German National Library
Harth, VolkerLook up in the Integrated Authority File of the German National Library
Heise, Jana-Kristin
Holleczek, BerndLook up in the Integrated Authority File of the German National Library
Kaaks, RudolfLook up in the Integrated Authority File of the German National Library
Keil, Thomas
Krist, Lilian
Leitzmann, Michael
Lieb, Wolfgang
Meinke-Franze, Claudia
Michels, KarinLook up in the Integrated Authority File of the German National Library
Velásquez, Ilais Moreno
Obi, Nadia
Panreck, Leo
Peters, Annette
Pischon, TobiasLook up in the Integrated Authority File of the German National Library
Schikowski, Tamara
Schmidt, Börge
Standl, Marie
Stang, Andreas
Völzke, Henry
Weber, Andrea
Zeeb, Hajo
Karch, AndréLook up in the Integrated Authority File of the German National Library
Issue Date: 2024
Type: Article
Language: English
Abstract: Objectives - The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear. - Methods - Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms). - Results - Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61). - Conclusions - Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.
URI: https://opendata.uni-halle.de//handle/1981185920/120227
http://dx.doi.org/10.25673/118268
Open Access: Open access publication
License: (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0(CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0
Journal Title: Journal of infection
Publisher: Elsevier
Publisher Place: Amsterdam [u.a.]
Volume: 89
Issue: 2
Original Publication: 10.1016/j.jinf.2024.106206
Page Start: 1
Page End: 7
Appears in Collections:Open Access Publikationen der MLU

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