Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/118621
Title: Economic burden of secondary hyperparathyroidism in Germany : a matched comparison
Author(s): Reichel, HelmutLook up in the Integrated Authority File of the German National Library
Seibert, EricLook up in the Integrated Authority File of the German National Library
Tillmann, Frank-PeterLook up in the Integrated Authority File of the German National Library
Barck, Isabella
Grava, Astride
Schneider, Kim Maren
Meise, DominicLook up in the Integrated Authority File of the German National Library
Issue Date: 2023
Type: Article
Language: English
Abstract: Purpose: Secondary hyperparathyroidism (SHPT) of renal origin is a progressive complication in chronic kidney disease (CKD) and is associated with serious osseous and non-osseous complications, CKD progression, and economic burden for healthcare systems worldwide. We aimed at assessing characteristics, healthcare resource utilization, and costs of incident SHPT patients in CKD stage 3 (CKD3) and 4 (CKD4), using administrative claims data. Methods: German claims data were used to identify CKD3 and CKD4 patients, who were stratified by the occurrence of incident SHPT. Patients with SHPT were matched 1:1 to non-SHPT patients with the same CKD stage using propensity scores. Matched groups were compared during a 2-year follow-up period. Results: Overall, 1156 CKD3 and 517 CKD4 incident SHPT patients and their respective matches were identified. Mean number of all-cause hospitalizations were significantly higher among SHPT patients (2.7 vs. 2.0 in CKD3, 2.8 vs. 1.5 in CKD4) during follow-up. Similarly, the mean number of outpatient encounters was significantly higher among the SHPT cohorts (95.0 vs. 64.3 in CKD3, 101.4 vs. 49.8 in CKD4). SHPT patients progressed to CKD5 more often (6.1% vs. 1.2% from CKD3, 26.7% vs. 2.9% from CKD4, both P < 0.01) resulting in a higher proportion of dialysis (6.1% vs. 1.3% in CKD3, 22.1% vs. 3.7% in CKD4, both P < 0.01). Consequently, average all-cause healthcare costs significantly increased per patient (€19,477 vs. €15,115 in CKD3, €25,921 vs. €12,265 in CKD4). Conclusions: Patients with CKD3&4 and incident SHPT of renal origin presented with significantly higher healthcare resource utilization and costs, as well as increased disease progression compared to non-SHPT patients.
URI: https://opendata.uni-halle.de//handle/1981185920/120579
http://dx.doi.org/10.25673/118621
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: International urology and nephrology
Publisher: Springer Science + Business Media B.V.
Publisher Place: Dordrecht [u.a.]
Volume: 55
Original Publication: 10.1007/s11255-022-03425-9
Page Start: 1291
Page End: 1300
Appears in Collections:Open Access Publikationen der MLU

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