Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/118752
Title: Bulbillosins A - E, azaphilones from Tengochaeta bulbillosa sp. nov. (Chaetomiaceae), a root endophyte of the Chinese medicinal plant Aster tataricus
Author(s): Barrera-Adame, Diana Astrid
Marin-Felix, Yasmina
Wegener, Ana Kristin
Lalk, MichaelLook up in the Integrated Authority File of the German National Library
Stadler, MarcLook up in the Integrated Authority File of the German National Library
Niedermeyer, Timo H. J.Look up in the Integrated Authority File of the German National Library
Issue Date: 2025
Type: Article
Language: English
Abstract: Aster tataricus is a plant used in Traditional Chinese Medicine. From its roots, we isolated four endophytic fungi strains. After mass spectrometry analysis and subsequent molecular networking and dereplication, one of the strain’s extracts showed a cluster of yet undescribed natural products. Additionally, the extract was found to be lethal for the nematode Caenorhabditis elegans and cytotoxic against eukaryotic cell lines. The fungal strain was characterized by morphological and molecular studies, allowing its description as a new species in the genus Tengochaeta (Chaetomiaceae), Tengochaeta bulbillosa. After cultivation and extraction of the strain, the major secondary metabolites were isolated. Structure elucidation based on nuclear magnetic resonance spectroscopy and high-resolution tandem mass spectrometry revealed these compounds to be five new azaphilones. Additionally, the localization of these azaphilones in the host plant was studied by mass spectrometry imaging of different plant tissues, revealing that they were mainly localized in the aerial parts of the plant. The main compound, bulbillosin A, was evaluated for its activity against sixty cancer cell lines, revealing a differential cytotoxicity profile.
URI: https://opendata.uni-halle.de//handle/1981185920/120710
http://dx.doi.org/10.25673/118752
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: IMA fungus
Publisher: Assoc.
Publisher Place: Utrecht
Volume: 16
Original Publication: 10.3897/imafungus.16.141036
Page Start: 1
Page End: 25
Appears in Collections:Open Access Publikationen der MLU

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