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http://dx.doi.org/10.25673/38239
Titel: | Ester and amide derivatives of rhodamine B exert cytotoxic effects on different human tumor cell lines |
Autor(en): | Serbian, Immo![]() Hoenke, Sophie Kraft, Oliver Csuk, René ![]() |
Erscheinungsdatum: | 2020 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | Three esters of rhodamine B (1–3) differing in their alkyl chain lengths as well as several rhodamine B amides (4–9) were synthesized in good yields and tested for their cytotoxicity in SRB assays employing several human tumor cell lines. The rhodamine B esters were unselective but showed cytotoxicity of as low as EC50 = 0.15 ± 0.02 µM. The rhodamine B amides were slightly less cytotoxic but showed good selectivity against MCF-7 and A2780 tumor cell lines. Especially a morpholinyl derivative 4 was ~20 time more cytotoxic for MCF-7 than for nonmalignant NIH 3T3 cells. |
URI: | https://opendata.uni-halle.de//handle/1981185920/38482 http://dx.doi.org/10.25673/38239 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Sponsor/Geldgeber: | Publikationsfond MLU |
Journal Titel: | Medicinal chemistry research |
Verlag: | Birkhäuser Boston |
Verlagsort: | Cambridge, Mass. [u.a.] |
Band: | 29 |
Heft: | 9 |
Originalveröffentlichung: | 10.1007/s00044-020-02591-8 |
Seitenanfang: | 1655 |
Seitenende: | 1661 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Serbian2020_Article_EsterAndAmideDerivativesOfRhod.pdf | 687.37 kB | Adobe PDF | ![]() Öffnen/Anzeigen |