Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/39745
Title: CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
Author(s): Pawlitzki, MarcLook up in the Integrated Authority File of the German National Library
Butryn, Michaela
Kirchner, Florian
Färber, JacquelineLook up in the Integrated Authority File of the German National Library
Beuing, OliverLook up in the Integrated Authority File of the German National Library
Minnerup, JensLook up in the Integrated Authority File of the German National Library
Meuth, SvenLook up in the Integrated Authority File of the German National Library
Neumann, Jens
Issue Date: 2019
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-417004
Subjects: Primary angiitis of the central nervous system (PACNS)
Biomarker
Neurofilament light chain (NFL)
Abstract: The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro-axonal damage and arterial-vessel abnormalities was observed with magnetic resonance imaging as well as with MR- and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker.
URI: https://opendata.uni-halle.de//handle/1981185920/41700
http://dx.doi.org/10.25673/39745
Open Access: Open access publication
License: (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0(CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0
Journal Title: Annals of Clinical and Translational Neurology
Publisher: Wiley
Publisher Place: Chichester [u.a.]
Volume: 6
Issue: 6
Original Publication: 10.1002/acn3.790
Page Start: 1134
Page End: 1137
Appears in Collections:Medizinische Fakultät (OA)

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