Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/64065
Title: Neurotrophin signalling in amygdala-dependent cued fear learning
Author(s): Meis, Susanne
Endres, ThomasLook up in the Integrated Authority File of the German National Library
Leßmann, VolkmarLook up in the Integrated Authority File of the German National Library
Issue Date: 2020
Type: Article
Language: English
URN: urn:nbn:de:gbv:ma9:1-1981185920-660160
Subjects: Amygdala
LTP
Fear
Extinction
BDNF
GABA
Abstract: The amygdala is a central hub for fear learning assessed by Pavlovian fear conditioning. Indeed, the prevailing hypothesis that learning and memory are mediated by changes in synaptic strength was shown most convincingly at thalamic and cortical afferents to the lateral amygdala. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to regulate synaptic plasticity and memory formation in many areas of the mammalian brain including the amygdala, where BDNF signalling via tropomyosin-related kinase B (TrkB) receptors is prominently involved in fear learning. This review updates the current understanding of BDNF/TrkB signalling in the amygdala related to fear learning and extinction. In addition, actions of proBDNF/ p75NTR and NGF/TrkA as well as NT-3/TrkC signalling in the amygdala are introduced.
URI: https://opendata.uni-halle.de//handle/1981185920/66016
http://dx.doi.org/10.25673/64065
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Sponsor/Funder: Projekt DEAL 2020
Journal Title: Cell & tissue research
Publisher: Springer
Publisher Place: Berlin
Volume: 382
Issue: 1
Original Publication: 10.1007/s00441-020-03260-3
Page Start: 161
Page End: 172
Appears in Collections:Medizinische Fakultät (OA)

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