Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/85371| Title: | Potential use of CTCs as biomarkers in renal cancer patients |
| Author(s): | Bialek, Joanna Wencker, Andreas Kawan, Felix Yankulov, Stefan Fornara, Paolo Theil, Gerit |
| Issue Date: | 2022 |
| Type: | Article |
| Language: | English |
| Abstract: | We demonstrated that the CellCollector is an appropriate tool for detecting CTCs in RCC patients. We examined EpCAM and MUC1 expression levels in RCC tissues and cell lines and analyzed the detection rate of CTCs in blood samples ex vivo using an anti-EpCAM antibody-covered straight or spiraled CellCollector. Eight matched samples were examined for affinity to the anti-EpCAM vs. anti-EpCAM/anti-MUC1 antibody-covered wire. The use of this combination of antibodies allowed us to classify patients with lung metastasis. Finally, four patients were analyzed in vivo. In conclusion, both straight (ex vivo, in vivo) and spiraled (ex vivo) wires detected CTCs. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/87323 http://dx.doi.org/10.25673/85371 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Sponsor/Funder: | Publikationsfonds MLU |
| Journal Title: | Life |
| Publisher: | MDPI |
| Publisher Place: | Basel |
| Volume: | 12 |
| Issue: | 1 |
| Original Publication: | 10.3390/life12010089 |
| Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| life-12-00089-v3.pdf | 2.76 MB | Adobe PDF |  View/Open |