Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/86331
Title: | MatriGrid® based biological morphologies: tools for 3D cell culturing |
Author(s): | Mai, Patrick Hampl, Jörg Baca, Martin ![]() Brauer, Dana ![]() Singh, Sukhdeep ![]() Weise, Frank ![]() Borowiec, Justyna ![]() Schmidt, André ![]() Küstner, Johanna Merle Klett, Maren Gebinoga, Michael Schroeder, Insa S. Markert, Udo R. ![]() Glahn, Felix Schumann, Berit ![]() Eckstein, Diana Schober, Andreas ![]() |
Issue Date: | 2022 |
Type: | Article |
Language: | English |
Abstract: | Recent trends in 3D cell culturing has placed organotypic tissue models at another level. Now, not only is the microenvironment at the cynosure of this research, but rather, microscopic geometrical parameters are also decisive for mimicking a tissue model. Over the years, technologies such as micromachining, 3D printing, and hydrogels are making the foundation of this field. However, mimicking the topography of a particular tissue-relevant substrate can be achieved relatively simply with so-called template or morphology transfer techniques. Over the last 15 years, in one such research venture, we have been investigating a micro thermoforming technique as a facile tool for generating bioinspired topographies. We call them MatriGrid®s. In this research account, we summarize our learning outcome from this technique in terms of the influence of 3D micro morphologies on different cell cultures that we have tested in our laboratory. An integral part of this research is the evolution of unavoidable aspects such as possible label-free sensing and fluidic automatization. The development in the research field is also documented in this account. |
URI: | https://opendata.uni-halle.de//handle/1981185920/88284 http://dx.doi.org/10.25673/86331 |
Open Access: | ![]() |
License: | ![]() |
Sponsor/Funder: | Publikationsfonds MLU |
Journal Title: | Bioengineering |
Publisher: | MDPI |
Publisher Place: | Basel |
Volume: | 9 |
Issue: | 5 |
Original Publication: | 10.3390/bioengineering9050220 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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bioengineering-09-00220.pdf | 34.24 MB | Adobe PDF | ![]() View/Open |