Please use this identifier to cite or link to this item:
http://dx.doi.org/10.25673/86398
Title: | Platanic acid derived amides are more cytotoxic than their corresponding oximes |
Author(s): | Kozubek, Marie Hoenke, Sophie Schmidt, Theresa Ströhl, Dieter Csuk, René |
Issue Date: | 2022 |
Type: | Article |
Language: | English |
Abstract: | Albeit platanic acid has been known since 1956, its potential to act as a valuable starting material for the synthesis of cytotoxic agents has been neglected for many years. Hereby we describe the synthesis of a small library of amides and oximes derived from 3-O-acetyl-platanic acid, and the results of their screening as cytotoxic agents for several human tumor cell lines. As a result, while the cytotoxicity of the oximes was diminished as compared to the parent amides, the homopiperazinyl amide 5 held the highest cytoxicity (EC50 = 0.9 μM for A375 human melanoma cells). Extra FACS and cell cycle measurements showed compound 5 to act onto A375 cells rather by apoptosis than by necrosis. |
URI: | https://opendata.uni-halle.de//handle/1981185920/88354 http://dx.doi.org/10.25673/86398 |
Open Access: | ![]() |
License: | ![]() |
Sponsor/Funder: | Publikationsfonds MLU |
Journal Title: | Medicinal chemistry research |
Publisher: | Birkhäuser Boston |
Publisher Place: | Cambridge, Mass. [u.a.] |
Volume: | 31 |
Original Publication: | 10.1007/s00044-022-02902-1 |
Page Start: | 1049 |
Page End: | 1059 |
Appears in Collections: | Open Access Publikationen der MLU |
Files in This Item:
File | Description | Size | Format | |
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Kozubek2022_Article_PlatanicAcidDerivedAmidesAreMo.pdf | 1.52 MB | Adobe PDF | ![]() View/Open |