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Titel: Effectiveness and tolerability of eptinezumab in treating patients with migraine resistant to conventional preventive medications and CGRP (receptor) antibodies : a multicentre retrospective real-world analysis from Germany
Autor(en): Scheffler, ArminIn der Gemeinsamen Normdatei der DNB nachschlagen
Wenzel, Pauline
Bendig, Merle
Eikermann, AstridIn der Gemeinsamen Normdatei der DNB nachschlagen
Basten, JaleIn der Gemeinsamen Normdatei der DNB nachschlagen
Kleinschnitz, ChristophIn der Gemeinsamen Normdatei der DNB nachschlagen
Nsaka, MichaelIn der Gemeinsamen Normdatei der DNB nachschlagen
Lindner, DianaIn der Gemeinsamen Normdatei der DNB nachschlagen
Naegel, Steffen
Burow, PhilippIn der Gemeinsamen Normdatei der DNB nachschlagen
Fleischmann, RobertIn der Gemeinsamen Normdatei der DNB nachschlagen
Holle-Lee, DagnyIn der Gemeinsamen Normdatei der DNB nachschlagen
Erscheinungsdatum: 2024
Art: Artikel
Sprache: Englisch
Zusammenfassung: Background: Eptinezumab is a monoclonal antibody that targets calcitonin gene-related peptide (CGRP mAb) and is used for migraine prophylaxis. Efficacy data are mainly from clinical trials, real-world data are hardly available yet. Reimbursement policy in Germany leads to eptinezumab mainly being used in patients having failed pre-treatment with other CGRP mAb. To date, it is unclear whether eptinezumab is efficacious and well tolerated in this population and how the treatment response differs from patients who are naive to CGRP mAbs. Methods: We analysed clinical routine data of 79 patients (episodic migraine (EM): n = 19; chronic migraine (CM): n = 60) from four different centres in Germany. All patients were treated with eptinezumab (100mg). Differences in monthly headache (MHD), migraine (MMD) and acute medication days (AMD) after three months were analysed. The correlation of response with the number of CGRP mAb failures was evaluated. Significance level has been corrected (alpha = 0.017). Results: After three months MHD, MMD and AMD were significantly reduced. In EM, the median reduction for MHD was 4.0 days (IQR: -6.5 to -1.0; p = 0.001), for MMD 3.0 days (IQR: -5.5 to -1.5; p < 0.001) and for AMD 2.0 days (IQR: -5.0 to -0.5; p = 0.006). In CM, median reduction of MHD was 4 days (IQR: -8.0 to 0.0; p < 0.001), 3.0 days (IQR: -6.0 to-1.0; p < 0.001) for MMD and 1.0 day (IQR: -5.0 to 0.0; p < 0.001) for AMD. All patients were resistant to conventional preventive therapies and most to CGRP mAbs. Fourteen patients had never received a CGRP mAb and 65 patients had received at least one mAb without sufficient effectiveness and/or intolerability (one: n = 20, two: n = 28, three: n = 17). There was a significant association between the number of prior therapies and the 30% MHD responder rate (none: 78.6%, one: 45.0%, two: 32.1%, three: 23.5%, p = 0.010). Regarding tolerability, 10.4% (8/77) reported mild side effects. Conclusions: The effectiveness of eptinezumab is significantly reduced in patients who have not previously responded to other CGRP mAbs. However, limitations such as the retrospective nature of the analysis, the small sample size and the short treatment period with only the lower dose of eptinezumab must be considered when interpreting the results.
URI: https://opendata.uni-halle.de//handle/1981185920/118464
http://dx.doi.org/10.25673/116509
Open-Access: Open-Access-Publikation
Nutzungslizenz: (CC BY 4.0) Creative Commons Namensnennung 4.0 International(CC BY 4.0) Creative Commons Namensnennung 4.0 International
Journal Titel: The journal of headache and pain
Verlag: Springer Italia
Verlagsort: Milano
Band: 25
Originalveröffentlichung: 10.1186/s10194-024-01788-1
Seitenanfang: 1
Seitenende: 9
Enthalten in den Sammlungen:Open Access Publikationen der MLU

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