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http://dx.doi.org/10.25673/116572
Titel: | Individualized neoantigen peptide immunization of a metastatic pancreatic cancer patient: a case report of combined tumor and liquid biopsy |
Autor(en): | Roehnisch, Tim Martos-Contreras, Mari Carmen Manoochehri, Mehdi Nogueira da Silva, Mauro ![]() Bremm, Franziska Dörrie, Jan ![]() Christoph, Jan ![]() Kunz, Meik ![]() Wolfgang, Schönharting |
Erscheinungsdatum: | 2024 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | This report details a case of pancreatic cancer with liver metastasis that exhibited a positive immune response to personalized immunization therapy. Our study involved the identification of neoantigens and their corresponding immunogenic peptides using an in-house bioinformatic pipeline. This process included the identification of somatic mutations through DNA/RNA sequencing of solid tumor tissue and blood liquid biopsy. Computational prediction techniques were then employed to identify novel epitopes, followed by the design and manufacture of patient-specific immunization peptides. In combination with standard-of-care chemotherapy, the patient received a sequence of 5 biweekly prime injections followed by 2 boost injections 2 and 5 months later. The peptides were emulsified in Montanide and the injection-site was conditioned with nivolumab and imiquimod. The combined regimen of peptide immunization and chemotherapy resulted in a notable decline in CA19-9 tumor marker levels following both prime and boost applications. Subsequent MRI assessments revealed a reduction in the size of liver metastases several months post-immunization initiation. Importantly, the patient showed and improved overall survival and reported an improved quality of life without experiencing significant treatment-related adverse effects. This case underscores the potential benefits of personalized peptide-based immunization as an adjunctive therapy in the treatment of advanced pancreatic cancer, showcasing promising outcomes in tumor marker reduction, tumor shrinkage, and enhanced patient well-being. |
URI: | https://opendata.uni-halle.de//handle/1981185920/118530 http://dx.doi.org/10.25673/116572 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Journal Titel: | Frontiers in immunology |
Verlag: | Frontiers Media |
Verlagsort: | Lausanne |
Band: | 15 |
Originalveröffentlichung: | 10.3389/fimmu.2024.1414737 |
Seitenanfang: | 1 |
Seitenende: | 5 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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fimmu-15-1414737.pdf | 1.98 MB | Adobe PDF | ![]() Öffnen/Anzeigen |