Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/117554
Title: Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food : Gerhard Eisenbrand, Andrea Buettner, Patrick Diel, Bernd Epe, Petra Först, Tillman Grune, Dirk Haller, Volker Heinz, Michael Hellwig, Hans-Ulrich Humpf, Henry Jäger, Sabine Kulling, Alfonso Lampen, Marcel Leist, Angela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Joachim Spranger, Pablo Steinberg, Stefan Vieths, Wim Wätjen, Jan G. Hengstler
Author(s): Eisenbrand, GerhardLook up in the Integrated Authority File of the German National Library
Büttner, AndreaLook up in the Integrated Authority File of the German National Library
Diel, Patrick ReneLook up in the Integrated Authority File of the German National Library
Epe, Bernd
Först, PetraLook up in the Integrated Authority File of the German National Library
Grune, Tillman
Haller, DirkLook up in the Integrated Authority File of the German National Library
Heinz, VolkerLook up in the Integrated Authority File of the German National Library
Hellwig, MichaelLook up in the Integrated Authority File of the German National Library
Humpf, Hans-UlrichLook up in the Integrated Authority File of the German National Library
Jäger, HenryLook up in the Integrated Authority File of the German National Library
Kulling, Sabine E.Look up in the Integrated Authority File of the German National Library
Lampen, AlfonsoLook up in the Integrated Authority File of the German National Library
Leist, MarcelLook up in the Integrated Authority File of the German National Library
Mally, AngelaLook up in the Integrated Authority File of the German National Library
Marko, DorisLook up in the Integrated Authority File of the German National Library
Nöthlings, UteLook up in the Integrated Authority File of the German National Library
Röhrdanz, Elke
Spranger, JoachimLook up in the Integrated Authority File of the German National Library
Steinberg, PabloLook up in the Integrated Authority File of the German National Library
Vieths, StefanLook up in the Integrated Authority File of the German National Library
Wätjen, WimLook up in the Integrated Authority File of the German National Library
Hengstler, Jan G.Look up in the Integrated Authority File of the German National Library
Issue Date: 2024
Type: Article
Language: English
Abstract: Dietary exposure to N-nitrosamines has recently been assessed by the European Food Safety Authority (EFSA) to result in margins of exposure that are conceived to indicate concern with respect to human health risk. However, evidence from more than half a century of international research shows that N-nitroso compounds (NOC) can also be formed endogenously. In this commentary of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG), the complex metabolic and physiological biokinetics network of nitrate, nitrite and reactive nitrogen species is discussed with emphasis on its influence on endogenous NOC formation. Pioneering approaches to monitor endogenous NOC have been based on steady-state levels of N-nitrosodimethylamine (NDMA) in human blood and on DNA adduct levels in blood cells. Further NOC have not been considered yet to a comparable extent, although their generation from endogenous or exogenous precursors is to be expected. The evidence available to date indicates that endogenous NDMA exposure could exceed dietary exposure by about 2–3 orders of magnitude. These findings require consolidation by refined toxicokinetics and DNA adduct monitoring data to achieve a credible and comprehensive human health risk assessment.
URI: https://opendata.uni-halle.de//handle/1981185920/119513
http://dx.doi.org/10.25673/117554
Open Access: Open access publication
License: (CC BY 4.0) Creative Commons Attribution 4.0(CC BY 4.0) Creative Commons Attribution 4.0
Journal Title: Archives of toxicology
Publisher: Springer
Publisher Place: Berlin
Volume: 98
Issue: 6
Original Publication: 10.1007/s00204-024-03726-1
Page Start: 1573
Page End: 1580
Appears in Collections:Open Access Publikationen der MLU

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