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http://dx.doi.org/10.25673/117944
Titel: | Rapid submillimeter QSM and R2* mapping using interleaved multishot 3D-EPI at 7 and 3 Tesla |
Autor(en): | Stirnberg, Rüdiger![]() Deistung, Andreas ![]() Reichenbach, Jürgen ![]() Breteler, Monique M. B. Stöcker, Tony |
Erscheinungsdatum: | 2024 |
Art: | Artikel |
Sprache: | Englisch |
Zusammenfassung: | Purpose: To explore the high signal-to-noise ratio (SNR) efficiency of inter- leaved multishot 3D-EPI with standard image reconstruction for fast and robust high-resolution whole-brain quantitative susceptibility (QSM) and R∗ 2 mapping at 7 and 3T. Methods: Single- and multi-TE segmented 3D-EPI is combined with con- ventional CAIPIRINHA undersampling for up to 72-fold effective gradient echo (GRE) imaging acceleration. Across multiple averages, scan parameters are varied (e.g., dual-polarity frequency-encoding) to additionally correct for B 0 -induced artifacts, geometric distortions and motion retrospectively. A com- parison to established GRE protocols is made. Resolutions range from 1.4 mm isotropic (1 multi-TE average in 36 s) up to 0.4 mm isotropic (2 single-TE averages in approximately 6 min) with whole-head coverage. Results: Only 1-4 averages are needed for sufficient SNR with 3D-EPI, depend- ing on resolution and field strength. Fast scanning and small voxels together with retrospective corrections result in substantially reduced image artifacts, which improves susceptibility and R∗ 2 mapping. Additionally, much finer details are obtained in susceptibility-weighted image projections through significantly reduced partial voluming. Conclusion: Using interleaved multishot 3D-EPI, single-TE and multi-TE data can readily be acquired 10 times faster than with conventional, accelerated GRE imaging. Even 0.4 mm isotropic whole-head QSM within 6 min becomes feasible at 7T. At 3T, motion-robust 0.8 mm isotropic whole-brain QSM and R∗ 2 map- ping with no apparent distortion in less than 7 min becomes clinically feasible. Stronger gradient systems may allow for even higher effective acceleration rates through larger EPI factors while maintaining optimal contrast. |
URI: | https://opendata.uni-halle.de//handle/1981185920/119904 http://dx.doi.org/10.25673/117944 |
Open-Access: | ![]() |
Nutzungslizenz: | ![]() |
Journal Titel: | Magnetic resonance in medicine |
Verlag: | Wiley-Liss |
Verlagsort: | New York, NY [u.a.] |
Band: | 92 |
Heft: | 6 |
Originalveröffentlichung: | 10.1002/mrm.30216 |
Seitenanfang: | 2294 |
Seitenende: | 2311 |
Enthalten in den Sammlungen: | Open Access Publikationen der MLU |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Magnetic Resonance in Med - 2024 - Stirnberg - Rapid submillimeter QSM and R2 mapping using interleaved multishot 3D‐EPI.pdf | 8.28 MB | Adobe PDF | ![]() Öffnen/Anzeigen |