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Titel: Rapid submillimeter QSM and R2* mapping using interleaved multishot 3D-EPI at 7 and 3 Tesla
Autor(en): Stirnberg, RüdigerIn der Gemeinsamen Normdatei der DNB nachschlagen
Deistung, AndreasIn der Gemeinsamen Normdatei der DNB nachschlagen
Reichenbach, JürgenIn der Gemeinsamen Normdatei der DNB nachschlagen
Breteler, Monique M. B.
Stöcker, Tony
Erscheinungsdatum: 2024
Art: Artikel
Sprache: Englisch
Zusammenfassung: Purpose: To explore the high signal-to-noise ratio (SNR) efficiency of inter- leaved multishot 3D-EPI with standard image reconstruction for fast and robust high-resolution whole-brain quantitative susceptibility (QSM) and R∗ 2 mapping at 7 and 3T. Methods: Single- and multi-TE segmented 3D-EPI is combined with con- ventional CAIPIRINHA undersampling for up to 72-fold effective gradient echo (GRE) imaging acceleration. Across multiple averages, scan parameters are varied (e.g., dual-polarity frequency-encoding) to additionally correct for B 0 -induced artifacts, geometric distortions and motion retrospectively. A com- parison to established GRE protocols is made. Resolutions range from 1.4 mm isotropic (1 multi-TE average in 36 s) up to 0.4 mm isotropic (2 single-TE averages in approximately 6 min) with whole-head coverage. Results: Only 1-4 averages are needed for sufficient SNR with 3D-EPI, depend- ing on resolution and field strength. Fast scanning and small voxels together with retrospective corrections result in substantially reduced image artifacts, which improves susceptibility and R∗ 2 mapping. Additionally, much finer details are obtained in susceptibility-weighted image projections through significantly reduced partial voluming. Conclusion: Using interleaved multishot 3D-EPI, single-TE and multi-TE data can readily be acquired 10 times faster than with conventional, accelerated GRE imaging. Even 0.4 mm isotropic whole-head QSM within 6 min becomes feasible at 7T. At 3T, motion-robust 0.8 mm isotropic whole-brain QSM and R∗ 2 map- ping with no apparent distortion in less than 7 min becomes clinically feasible. Stronger gradient systems may allow for even higher effective acceleration rates through larger EPI factors while maintaining optimal contrast.
URI: https://opendata.uni-halle.de//handle/1981185920/119904
http://dx.doi.org/10.25673/117944
Open-Access: Open-Access-Publikation
Nutzungslizenz: (CC BY-NC 4.0) Creative Commons Namensnennung - Nicht kommerziell 4.0 International(CC BY-NC 4.0) Creative Commons Namensnennung - Nicht kommerziell 4.0 International
Journal Titel: Magnetic resonance in medicine
Verlag: Wiley-Liss
Verlagsort: New York, NY [u.a.]
Band: 92
Heft: 6
Originalveröffentlichung: 10.1002/mrm.30216
Seitenanfang: 2294
Seitenende: 2311
Enthalten in den Sammlungen:Open Access Publikationen der MLU